Gene

aurka

ID

ZDB-GENE-040801-161

Name

aurora kinase A

Symbol

aurka Nomenclature History

Previous Names

fb37c10
fc02c02
wu:fb37c10
wu:fc02c02
zgc:100912

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Acts upstream of or within mitotic cell cycle. Predicted to be located in cytoplasm; microtubule; and spindle. Predicted to be part of chromosome passenger complex. Predicted to be active in kinetochore; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including caudal fin; immature eye; nervous system; somite; and spinal cord neural tube. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine cancer. Orthologous to human AURKA (aurora kinase A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from Jeon et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With aurka Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
colorectal cancer	Alliance	{Colon cancer, susceptibility to}	114500

Associated With aurka Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR030611	Aurora kinase A
Family	IPR030616	Aurora kinase-like
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily