Gene
atg5
- ID
- ZDB-GENE-040801-149
- Name
- ATG5 autophagy related 5 homolog (S. cerevisiae)
- Symbol
- atg5 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to contribute to Atg8 ligase activity. Involved in several processes, including autophagosome assembly; heart development; and regulation of skeletal muscle tissue regeneration. Predicted to localize to Atg12-Atg5-Atg16 complex and phagophore assembly site membrane. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 25. Is expressed in several structures, including central nervous system; head; liver; muscle; and tail bud. Orthologous to human ATG5 (autophagy related 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7145909 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 20 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive spinocerebellar ataxia 25 | Alliance | ?Spinocerebellar ataxia, autosomal recessive 25 | 617584 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR048318 | Autophagy protein ATG5, UblB domain |
| Domain | IPR048939 | Autophagy protein ATG5, UblA domain |
| Domain | IPR048940 | Autophagy protein ATG5, alpha-helical bundle region |
| Family | IPR007239 | Autophagy-related protein 5 |
| Homologous_superfamily | IPR042526 | Autophagy protein Atg5, helix rich domain |
| Homologous_superfamily | IPR042527 | Autophagy protein Atg5, UblA domain superfamily |
Domain Details Per Protein
| Protein | Length | Autophagy protein ATG5, alpha-helical bundle region | Autophagy protein Atg5, helix rich domain | Autophagy protein ATG5, UblA domain | Autophagy protein Atg5, UblA domain superfamily | Autophagy protein ATG5, UblB domain | Autophagy-related protein 5 |
|---|---|---|---|---|---|---|---|
|
UniProtKB:F1RDC0
|
275 |
Interactions and Pathways
No data available
Plasmids
No data available