ZFIN is now using GRCz12tu for Genomic Data
Gene

meox1

ID
ZDB-GENE-040718-149
Name
mesenchyme homeobox 1
Symbol
meox1 Nomenclature History
Previous Names
  • mox2 (1)
  • mox (1)
  • cho
  • choker (1)
  • id:ibd2838
  • zgc:92343
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Genome Assembly
GRCz12tu
Annotation Status
Current
Description
Enables DNA-binding transcription factor activity; chromatin binding activity; and sequence-specific DNA binding activity. Involved in hematopoietic stem cell differentiation and somite development. Acts upstream of or within several processes, including developmental pigmentation; muscle cell development; and skeletal system development. Located in nucleus. Is expressed in several structures, including fast muscle myoblast; medial rectus; paraxial mesoderm; pectoral fin; and tail bud. Used to study Klippel-Feil syndrome. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome 2. Orthologous to human MEOX1 (mesenchyme homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
23 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With meox1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Klippel-Feil syndrome 2 Alliance Klippel-Feil syndrome 2 214300
Associated With meox1 Via Experimental Models
Human Disease Fish Conditions Citations
Klippel-Feil syndrome meox1tm26/tm26 (TU) standard conditions Dauer et al., 2018
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeodomain
Domain IPR020479 Homeodomain, metazoa
Family IPR042634 Homeobox protein MOX-1/MOX-2
Homologous_superfamily IPR009057 Homedomain-like superfamily
Domain Details Per Protein
Protein Additional Resources Length Homedomain-like superfamily Homeobox, conserved site Homeobox protein MOX-1/MOX-2 Homeodomain Homeodomain, metazoa
UniProtKB:F1Q4R9 InterPro 253
UniProtKB:A0A8M9PW63 InterPro 181
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA meox1-201 (1)
Ensembl
Ensembl 2,771 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-meox1
  • IHC
 2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Genome Browsers
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.