Gene
pou1f1
- ID
- ZDB-GENE-040630-7
- Name
- POU class 1 homeobox 1
- Symbol
- pou1f1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within cell fate specification. Predicted to be located in nucleus. Is expressed in adenohypophyseal placode; adenohypophysis; brain; and hypophysis. Human ortholog(s) of this gene implicated in panhypopituitarism and pituitary gland disease. Orthologous to human POU1F1 (POU class 1 homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu451 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Phenotype Annotation (1994-2006)
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
hypopituitarism | Alliance | Pituitary hormone deficiency, combined or isolated, 1 | 613038 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR017970 | Homeobox, conserved site |
Domain | IPR000327 | POU-specific domain |
Domain | IPR001356 | Homeobox domain |
Domain | IPR013847 | POU domain |
Family | IPR015586 | Pituitary-specific positive transcription factor 1 |
Homologous_superfamily | IPR009057 | Homeobox-like domain superfamily |
Homologous_superfamily | IPR010982 | Lambda repressor-like, DNA-binding domain superfamily |
Domain Details Per Protein
Protein | Length | Homeobox, conserved site | Homeobox domain | Homeobox-like domain superfamily | Lambda repressor-like, DNA-binding domain superfamily | Pituitary-specific positive transcription factor 1 | POU domain | POU-specific domain |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q6TGI2
|
141 | |||||||
UniProtKB:A0A2R8RYW1
|
350 | |||||||
UniProtKB:Q6TGI3
|
150 | |||||||
UniProtKB:Q6TGI4
|
350 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
pou1f1-201
(1)
|
1170 nt |
Interactions and Pathways
No data available
Plasmids
No data available