Gene

pou1f1

ID

ZDB-GENE-040630-7

Name

POU class 1 homeobox 1

Symbol

pou1f1 Nomenclature History

Previous Names

pit-1 (1)
Pit1 (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription by RNA polymerase II. Acts upstream of or within cell fate specification. Predicted to be located in nucleus. Is expressed in adenohypophyseal placode; adenohypophysis; brain; and hypophysis. Human ortholog(s) of this gene implicated in panhypopituitarism and pituitary gland disease. Orthologous to human POU1F1 (POU class 1 homeobox 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

25 figures from 17 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu451 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Phenotype Annotation (1994-2006)
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pou1f1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypopituitarism	Alliance	Pituitary hormone deficiency, combined or isolated, 1	613038

Associated With pou1f1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR000327	POU-specific domain
Domain	IPR001356	Homeobox domain
Domain	IPR013847	POU domain
Family	IPR015586	Pituitary-specific positive transcription factor 1
Homologous_superfamily	IPR009057	Homeobox-like domain superfamily
Homologous_superfamily	IPR010982	Lambda repressor-like, DNA-binding domain superfamily