Gene
tph2
- ID
- ZDB-GENE-040624-4
- Name
- tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)
- Symbol
- tph2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have tryptophan 5-monooxygenase activity. Involved in regulation of hematopoietic stem cell differentiation. Predicted to localize to neuron projection. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; major depressive disorder; and panic disorder. Is expressed in brain and neurons. Orthologous to human TPH2 (tryptophan hydroxylase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 38 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| melancholic depression | Alliance | {Unipolar depression, susceptibility to} | 608516 |
| {?Attention deficit-hyperactivity disorder, susceptibility to, 7} | 613003 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018301 | Aromatic amino acid hydroxylase, iron/copper binding site |
| Domain | IPR002912 | ACT domain |
| Domain | IPR019774 | Aromatic amino acid hydroxylase, C-terminal |
| Domain | IPR041904 | Tryptophan 5-hydroxylase, catalytic domain |
| Family | IPR001273 | Aromatic amino acid hydroxylase |
| Family | IPR005963 | Tryptophan 5-monooxygenase |
| Family | IPR019773 | Tyrosine 3-monooxygenase-like |
| Homologous_superfamily | IPR036329 | Aromatic amino acid monoxygenase, C-terminal domain superfamily |
| Homologous_superfamily | IPR036951 | Aromatic amino acid hydroxylase superfamily |
| Homologous_superfamily | IPR045865 | ACT-like domain |
Domain Details Per Protein
| Protein | Length | ACT domain | ACT-like domain | Aromatic amino acid hydroxylase | Aromatic amino acid hydroxylase, C-terminal | Aromatic amino acid hydroxylase, iron/copper binding site | Aromatic amino acid hydroxylase superfamily | Aromatic amino acid monoxygenase, C-terminal domain superfamily | Tryptophan 5-hydroxylase, catalytic domain | Tryptophan 5-monooxygenase | Tyrosine 3-monooxygenase-like |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1P7E6
|
546 | ||||||||||
|
UniProtKB:Q1LUE3
|
473 |
Interactions and Pathways
No data available
Plasmids
No data available