Gene
tph2
- ID
- ZDB-GENE-040624-4
- Name
- tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)
- Symbol
- tph2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable tryptophan 5-monooxygenase activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be active in neuron projection. Is expressed in brain and neurons. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; anxiety disorder (multiple); autistic disorder; and drug dependence (multiple). Orthologous to human TPH2 (tryptophan hydroxylase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 39 figures from 31 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ct817 | Allele with one delins | Exon 6 | Frameshift, Premature Stop | zinc finger nuclease | |
| ion39Tg | Transgenic insertion | Intron 9 | Unknown | DNA and CRISPR | |
| nv1089 | Allele with one deletion | Exon 7 | Unknown | CRISPR | |
| sa8576 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| melancholic depression | Alliance | {Unipolar depression, susceptibility to} | 608516 |
| {?Attention deficit-hyperactivity disorder, susceptibility to, 7} | 613003 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018301 | Aromatic amino acid hydroxylase, iron/copper binding site |
| Domain | IPR002912 | ACT domain |
| Domain | IPR019774 | Aromatic amino acid hydroxylase, C-terminal |
| Domain | IPR041904 | Tryptophan 5-hydroxylase, catalytic domain |
| Family | IPR001273 | Aromatic amino acid hydroxylase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ACT domain | ACT-like domain | Aromatic amino acid hydroxylase | Aromatic amino acid hydroxylase, C-terminal | Aromatic amino acid hydroxylase, iron/copper binding site | Aromatic amino acid hydroxylase superfamily | Aromatic amino acid monoxygenase, C-terminal domain superfamily | Tryptophan 5-hydroxylase, catalytic domain | Tryptophan 5-monooxygenase | Tyrosine 3-monooxygenase-like |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1P7E6 | InterPro | 546 | ||||||||||
| UniProtKB:Q1LUE3 | InterPro | 473 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(tph2:ChR2-YFP) |
|
| 1 | (2) | |
| Tg(tph2:Eco.NfsB-mCherry) |
|
| 4 | (10) | |
| Tg(tph2:EGFP) |
|
| 1 | (3) | |
| Tg(tph2:eNTR-YFP) |
|
| 1 | (3) | |
| Tg(tph2:epNTR-TagRFPT) |
|
| 1 | (3) | |
| Tg(tph2:GAL4FF) |
|
| 8 | (19) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-218C6 | ZFIN Curated Data | |
| Encodes | EST | fq15a04 | Rauch et al., 2003 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001310068 (1) | 2224 nt | ||
| Genomic | GenBank:BX323598 (1) | 197329 nt | ||
| Polypeptide | UniProtKB:A0A8M1P7E6 (1) | 546 aa |
- Godino-Gimeno, A., Rocha, A., Chivite, M., Saera-Vila, A., Rotllant, J., Míguez, J.M., Cerdá-Reverter, J.M. (2024) Agouti-induced anxiety-like behaviour is mediated by central serotonergic pathways in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 44(32):
- Miyazaki, S., Shimizu, N., Miyahara, H., Teranishi, H., Umeda, R., Yano, S., Shimada, T., Shiraishi, H., Komiya, K., Katoh, A., Yoshimura, A., Hanada, R., Hanada, T. (2024) DHCR7 links cholesterol synthesis with neuronal development and axonal integrity. Biochemical and Biophysical Research Communications. 712-713:149932149932
- Tea, M., Pan, Y.K., Lister, J.G.R., Perry, S.F., Gilmour, K.M. (2024) Effects of serta and sertb knockout on aggression in zebrafish (Danio rerio). Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. 210(5):785-799
- Wang, H., Li, X., Li, J., Yu, F., Li, Q., Qin, M., Gui, L., Qian, Y., Huang, M. (2024) Long-term exposure to ionic liquid [C8mim]Br induces the potential risk of anxiety and memory deterioration through disturbing neurotransmitter systems. Neurotoxicology. 104:66-74
- Cao, M., Xu, T., Zhang, H., Wei, S., Wang, H., Song, Y., Guo, X., Chen, D., Yin, D. (2023) BDE-47 Causes Depression-like Effects in Zebrafish Larvae via a Non-Image-Forming Visual Mechanism. Environmental science & technology. 57(26):9592-9602
- Chen, F., Köhler, M., Cucun, G., Takamiya, M., Kizil, C., Cosacak, M.I., Rastegar, S. (2023) sox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons. iScience. 26:107342107342
- Ichikawa, S., Abe, R., Fujimoto, H., Higashi, K., Zang, L., Nakayama, H., Matsuoka, I., Shimada, Y. (2023) Paraburkholderia sabiae administration alters zebrafish anxiety-like behavior via gut microbial taurine metabolism. Frontiers in microbiology. 14:10791871079187
- Shainer, I., Kuehn, E., Laurell, E., Al Kassar, M., Mokayes, N., Sherman, S., Larsch, J., Kunst, M., Baier, H. (2023) A single-cell resolution gene expression atlas of the larval zebrafish brain. Science advances. 9:eade9909
- Gabellini, C., Pucci, C., De Cesari, C., Martini, D., Di Lauro, C., Digregorio, M., Norton, W., Zippo, A., Sessa, A., Broccoli, V., Andreazzoli, M. (2022) CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene setd5 Leads to Social Impairments in Zebrafish. International Journal of Molecular Sciences. 24(1):
- Gonçalves, C., Kareklas, K., Teles, M.C., Varela, S.A.M., Costa, J., Leite, R.B., Paixão, T., Oliveira, R.F. (2022) Phenotypic architecture of sociality and its associated genetic polymorphisms in zebrafish. Genes, brain, and behavior. 21(5):e12809
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