Gene
asic4b
- ID
- ZDB-GENE-040513-6
- Name
- acid-sensing (proton-gated) ion channel family member 4b
- Symbol
- asic4b Nomenclature History
- Previous Names
-
- accn4b
- zASIC4.2 (1)
- zgc:111839
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Enables monoatomic cation channel activity. Acts upstream of or within response to steroid hormone. Located in plasma membrane. Is expressed in brain; eye; gill; ovary; and photoreceptor cell. Orthologous to human ASIC4 (acid sensing ion channel subunit family member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Zimmer et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa12799 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa14893 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16524 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33831 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40654 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa44632 | Allele with one point mutation | Unknown | Unknown | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Epithelial sodium channel | Epithelial sodium channel, conserved site |
|---|---|---|---|---|
| UniProtKB:Q708S3 | InterPro | 558 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
asic4b-201
(1)
|
Ensembl | 2,316 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-asic4b | polyclonal | Rabbit |
|
4 | |||
| Ab2-asic4b | polyclonal | Rat |
|
1 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-260I9 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-226N16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:111839 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_214786 (1) | 2296 nt | ||
| Genomic | GenBank:CR853290 (1) | 196624 nt | ||
| Polypeptide | UniProtKB:Q708S3 (1) | 558 aa |
- Cocco, A. (2018) The γ-aminobutyric acid and proton signaling systems in the zebrafish brain Characterization and effect of stress. Ph.D. Thesis.
- Zimmer, A.M., Dymowska, A.K., Kumai, Y., Goss, G.G., Perry, S.F., Kwong, R.W.M. (2018) Assessing the role of the acid-sensing ion channel asic4b in sodium uptake by larval zebrafish. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 226:1-10
- Klangnurak, W., Tokumoto, T. (2017) Fine selection of up-regulated genes during ovulation by in vivo induction of oocyte maturation and ovulation in zebrafish.. Zoological letters. 3:2
- Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Dymowska, A.K., Boyle, D., Schultz, A.G., Goss, G.G. (2015) The role of acid-sensing ion channels (ASICs) in epithelial Na+ uptake in adult zebrafish (Danio rerio). The Journal of experimental biology. 218(Pt 8):1244-51
- Viña, E., Parisi, V., Sánchez-Ramos, C., Cabo, R., Guerrera, M.C., Quirós, L.M., Germanà, A., Vega, J.A., García-Suárez, O. (2015) Acid-sensing ion channels (ASICs) 2 and 4.2 are expressed in the retina of the adult zebrafish. Cell and tissue research. 360(2):223-31
- Dymowska, A.K., Schultz, A.G., Blair, S.D., Chamot, D., Goss, G.G. (2014) Acid-sensing ion channels are involved in epithelial Na+ uptake in the rainbow trout Oncorhynchus mykiss. American journal of physiology. Cell physiology. 307(3):C255-65
- Graham, D.M., Huang, L., Robinson, K.R., and Messerli, M.A. (2013) Epidermal keratinocyte polarity and motility require Ca2+ influx through TRPV1. Journal of Cell Science. 126(Pt 20):4602-13
- Viña, E., Parisi, V., Cabo, R., Laurà, R., López-Velasco, S., López-Muñiz, A., García-Suárez, O., Germanà, A., and Vega, J.A. (2013) Acid-sensing ion channels (ASICs) in the taste buds of adult zebrafish. Neuroscience letters. 536:35-40
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