Gene
pals2b
- ID
- ZDB-GENE-040426-775
- Name
- protein associated with LIN7 2, MAGUK p55 family member b
- Symbol
- pals2b Nomenclature History
- Previous Names
-
- mpp6
- mpp6b
- zgc:55662
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Acts upstream of or within glial cell development and retina development in camera-type eye. Predicted to be located in membrane. Predicted to be active in cell-cell junction and plasma membrane. Is expressed in epiphysis and retina. Orthologous to human PALS2 (protein associated with LIN7 2, MAGUK p55 family member).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55662 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Charlton-Perkins et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pals2b | Giera et al., 2018 | |
| CRISPR2-pals2b | Charlton-Perkins et al., 2019 | |
| CRISPR3-pals2b | Charlton-Perkins et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Guanylate kinase, conserved site | Guanylate kinase-like domain | Guanylate kinase/L-type calcium channel beta subunit | L27 domain | L27 domain, C-terminal | L27 domain superfamily | Membrane-associated guanylate kinase | PDZ domain | PDZ superfamily | P-loop containing nucleoside triphosphate hydrolase | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BHB1 | InterPro | 580 | ||||||||||||
| UniProtKB:A0A8M9PAV5 | InterPro | 543 | ||||||||||||
| UniProtKB:Q1LW94 | InterPro | 539 | ||||||||||||
| UniProtKB:A0AB32T5J4 | InterPro | 543 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-22M8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55662 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198266 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044777 (1) | 2095 nt | ||
| Genomic | GenBank:BX640464 (1) | 255824 nt | ||
| Polypeptide | UniProtKB:A0A8M2BHB1 (1) | 580 aa |
- Charlton-Perkins, M., Almeida, A.D., MacDonald, R.B., Harris, W.A. (2019) Genetic control of cellular morphogenesis in Müller glia. Glia. 67(7):1401-1411
- Li, J.Y., Wang, Y.Y., Shao, T., Fan, D.D., Lin, A.F., Xiang, L.X., Shao, J.Z. (2019) The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E-mediated pyroptosis. The Journal of biological chemistry. 295(4):1120-1141
- Giera, S., Luo, R., Ying, Y., Ackerman, S.D., Jeong, S.J., Stoveken, H.M., Folts, C.J., Welsh, C.A., Tall, G.G., Stevens, B., Monk, K.R., Piao, X. (2018) Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells. eLIFE. 7
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ubuka, T., Tsutsui, K. (2014) Evolution of gonadotropin-inhibitory hormone receptor and its ligand. General and comparative endocrinology. 209:148-61
- Zhang, Y., Li, S., Liu, Y., Lu, D., Chen, H., Huang, X., Liu, X., Meng, Z., Lin, H., and Cheng, C.H. (2010) Structural diversity of the gnih/gnih receptor system in teleost: its involvement in early development and the negative control of LH release. Peptides. 31(6):1034-1043
- Yeo, G.H., Cheah, F.S., Winkler, C., Jabs, E.W., Venkatesh, B., and Chong, S.S. (2009) Phylogenetic and evolutionary relationships and developmental expression patterns of the zebrafish twist gene family. Development genes and evolution. 219(6):289-300
- Sundström, G., Larsson, T.A., Brenner, S., Venkatesh, B., and Larhammar, D. (2008) Evolution of the neuropeptide Y family: New genes by chromosome duplications in early vertebrates and in teleost fishes. General and comparative endocrinology. 155(3):705-716
- Sundström, G., Larsson, T.A., Larhammar, D. (2008) Phylogenetic and chromosomal analyses of multiple gene families syntenic with vertebrate Hox clusters. BMC Evolutionary Biology. 8(1):254
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