ZFIN is now using GRCz12tu for Genomic Data
Gene
timp2b
- ID
- ZDB-GENE-040426-2655
- Name
- TIMP metallopeptidase inhibitor 2b
- Symbol
- timp2b Nomenclature History
- Previous Names
-
- timp2l
- zgc:65967
- zgc:85799
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable metalloendopeptidase inhibitor activity. Acts upstream of or within glial cell development and retina development in camera-type eye. Predicted to be active in extracellular matrix and extracellular space. Is expressed in caudal vein plexus; liver; ovarian follicle; and vasculature. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human TIMP2 (TIMP metallopeptidase inhibitor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:65967 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Charlton-Perkins et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Netrin domain | Protease inhibitor I35 (TIMP) | Proteinase inhibitor I35b (TIMP), C-terminal | Tissue inhibitor of metalloproteinases-like, OB-fold |
|---|---|---|---|---|---|---|
| UniProtKB:Q6NUX9 | InterPro | 217 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
timp2b-201
(1)
|
Ensembl | 2,938 nt | ||
| mRNA |
timp2b-202
(1)
|
Ensembl | 1,989 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers