Gene
pacsin2
- ID
- ZDB-GENE-040426-2596
- Name
- protein kinase C and casein kinase substrate in neurons 2
- Symbol
- pacsin2 Nomenclature History
- Previous Names
-
- zgc:77519
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable phospholipid binding activity. Acts upstream of or within cilium assembly and regulation of endocytosis. Predicted to be located in several cellular components, including caveola; endosome; and ruffle membrane. Predicted to be active in endosome and plasma membrane. Is expressed in several structures, including anterior axial hypoblast; axial mesoderm; axis; hatching gland; and pleuroperitoneal region. Orthologous to human PACSIN2 (protein kinase C and casein kinase substrate in neurons 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77519 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa13662 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16198 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20325 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| umc405 | Allele with one delins | Unknown | Unknown | CRISPR | |
| umc406 | Allele with one delins | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pacsin1b,pacsin2 | Insinna et al., 2019 | |
| CRISPR1-pacsin2 | Insinna et al., 2019 | |
| CRISPR2-pacsin2 | Morgan et al., 2022 | |
| MO1-pacsin2 | N/A | Morgan et al., 2022 |
| MO2-pacsin2 | N/A | Morgan et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AH/BAR domain superfamily | F-BAR domain | FCH domain | PACSIN2, F-BAR domain | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QB37 | InterPro | 444 | ||||||
| UniProtKB:A0A8M9Q5U4 | InterPro | 443 | ||||||
| UniProtKB:A0A0R4IHF0 | InterPro | 491 | ||||||
| UniProtKB:F1QC13 | InterPro | 490 | ||||||
| UniProtKB:A0AB32TQP4 | InterPro | 444 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pacsin2-201
(1)
|
Ensembl | 2,327 nt | ||
| mRNA |
pacsin2-202
(1)
|
Ensembl | 619 nt | ||
| mRNA |
pacsin2-203
(1)
|
Ensembl | 578 nt | ||
| mRNA |
pacsin2-205
(1)
|
Ensembl | 3,120 nt | ||
| ncRNA |
pacsin2-002
(1)
|
Ensembl | 372 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-pacsin2 | polyclonal | Sheep |
|
1 |
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Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-378E14 | ZFIN Curated Data | |
| Contained in | Fosmid | ZFOS-2131B9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77519 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_207069 (1) | 2332 nt | ||
| Genomic | GenBank:CU695158 (2) | 39399 nt | ||
| Polypeptide | UniProtKB:A0A0R4IHF0 (1) | 491 aa |
- Morgan, J., Yarwood, R., Starborg, T., Yan, G., Lowe, M. (2022) Pacsin2 is required for endocytosis in the zebrafish pronephric tubule. Biology Open. 11(6):
- Ying, Y., Hu, X., Han, P., Mendez-Bermudez, A., Bauwens, S., Eid, R., Tan, L., Pousse, M., Giraud-Panis, M.J., Lu, Y., Gilson, E., Ye, J. (2022) The non-telomeric evolutionary trajectory of TRF2 in zebrafish reveals its specific roles in neurodevelopment and aging. Nucleic acids research. 50(4):2081-2095
- Insinna, C., Lu, Q., Teixeira, I., Harned, A., Semler, E.M., Stauffer, J., Magidson, V., Tiwari, A., Kenworthy, A.K., Narayan, K., Westlake, C.J. (2019) Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport. Nature communications. 10:428
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Edeling, M.A., Sanker, S., Shima, T., Umasankar, P.K., Höning, S., Kim, H.Y., Davidson, L.A., Watkins, S.C., Tsang, M., Owen, D.J., and Traub, L.M. (2009) Structural requirements for PACSIN/Syndapin operation during zebrafish embryonic notochord development. PLoS One. 4(12):e8150
- Steinke, D., Salzburger, W., Braasch, I., and Meyer, A. (2006) Many genes in fish have species-specific asymmetric rates of molecular evolution. BMC Genomics. 7(1):20
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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