Gene
pdhb
- ID
- ZDB-GENE-040426-2173
- Name
- pyruvate dehydrogenase E1 subunit beta
- Symbol
- pdhb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable pyruvate dehydrogenase (acetyl-transferring) activity. Acts upstream of or within pigmentation. Predicted to be located in mitochondrion. Predicted to be part of pyruvate dehydrogenase complex. Is expressed in alar plate midbrain region; musculature system; optic tectum; optic vesicle; and pronephric duct. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHB (pyruvate dehydrogenase E1 subunit beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64062 (6 images)
- IMAGE:6895600 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pyruvate decarboxylase deficiency | Alliance | Pyruvate dehydrogenase E1-beta deficiency | 614111 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005475 | Transketolase-like, pyrimidine-binding domain |
| Domain | IPR033248 | Transketolase, C-terminal domain |
| Family | IPR027110 | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial-type |
| Homologous_superfamily | IPR009014 | Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II |
| Homologous_superfamily | IPR029061 | Thiamin diphosphate-binding fold |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial-type | Thiamin diphosphate-binding fold | Transketolase, C-terminal domain | Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II | Transketolase-like, pyrimidine-binding domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q7T368 | InterPro | 359 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-87E7 | ZFIN Curated Data | |
| Encodes | EST | fc76a05 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6895600 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:64062 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213154 (1) | 1429 nt | ||
| Genomic | GenBank:BX649457 (2) | 159207 nt | ||
| Polypeptide | UniProtKB:Q7T368 (1) | 359 aa |
- Singh, M.K., Jayarajan, R., Varshney, S., Upadrasta, S., Singh, A., Yadav, R., Scaria, V., Sengupta, S., Shanmugam, D., Shalimar, ., Sivasubbu, S., Gandotra, S., Sachidanandan, C. (2021) Chronic systemic exposure to IL6 leads to deregulation of glycolysis and fat accumulation in the zebrafish liver. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1866(5):158905
- Zhang, J., Qian, L., Wang, C., Teng, M., Duan, M., Chen, X., Li, X., Wang, C. (2020) UPLC-TOF-MS/MS metabolomics analysis of zebrafish metabolism by spirotetramat. Environmental pollution (Barking, Essex : 1987). 266:115310
- Li, Y., Agrawal, I., Gong, Z. (2019) Reversion of tumor hepatocytes to normal hepatocytes during liver tumor regression in an oncogene transgenic zebrafish model. Disease models & mechanisms. 12(10):
- Qiu, L., Jia, K., Huang, L., Liao, X., Guo, X., Lu, H. (2019) Hepatotoxicity of tricyclazole in zebrafish (Danio rerio). Chemosphere. 232:171-179
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Chen, K., Cole, R.B., and Rees, B.B. (2013) Hypoxia-induced changes in the zebrafish (Danio rerio) skeletal muscle proteome. Journal of proteomics. 78:477-485
- Maurer, C.M., Schönthaler, H.B., Mueller, K.P., and Neuhauss, S.C. (2010) Distinct retinal deficits in a zebrafish pyruvate dehydrogenase-deficient mutant. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(36):11962-11972
- Kolmakov, N.N., Kube, M., Reinhardt, R., and Canario, A.V. (2008) Analysis of the goldfish Carassius auratus olfactory epithelium transcriptome reveals the presence of numerous non-olfactory GPCR and putative receptors for progestin pheromones. BMC Genomics. 9:429
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
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