pyroxd1

ID

ZDB-GENE-040426-1732

Name

pyridine nucleotide-disulphide oxidoreductase domain 1

Symbol

pyroxd1 Nomenclature History

Previous Names

ryroxd1 (1)
zgc:73254

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable flavin adenine dinucleotide binding activity and oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor. Predicted to be located in nucleus and sarcomere. Is expressed in female organism and trunk musculature. Human ortholog(s) of this gene implicated in myofibrillar myopathy 8. Orthologous to human PYROXD1 (pyridine nucleotide-disulphide oxidoreductase domain 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:73254 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from O'Grady et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pyroxd1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
myofibrillar myopathy 8	Alliance	Myopathy, myofibrillar, 8	617258

Associated With pyroxd1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR023753	FAD/NAD(P)-binding domain
Domain	IPR041575	NADH-rubredoxin oxidoreductase, C-terminal
Family	IPR050260	FAD-dependent oxidoreductase
Homologous_superfamily	IPR016156	FAD/NAD-linked reductase, dimerisation domain superfamily
Homologous_superfamily	IPR036188	FAD/NAD(P)-binding domain superfamily