Gene
lin7a
- ID
- ZDB-GENE-040426-1665
- Name
- lin-7 homolog A (C. elegans)
- Symbol
- lin7a Nomenclature History
- Previous Names
-
- zgc:73090
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in neurotransmitter secretion; regulation of synaptic assembly at neuromuscular junction; and synaptic vesicle transport. Predicted to be located in bicellular tight junction and plasma membrane. Predicted to be part of MPP7-DLG1-LIN7 complex. Predicted to be active in basolateral plasma membrane; cell-cell junction; and synapse. Is expressed in myotome and nervous system. Orthologous to human LIN7A (lin-7 homolog A, crumbs cell polarity complex component).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:73090 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | L27 domain | L27 domain, C-terminal | L27 domain superfamily | Membrane-associated multiprotein complex regulator | PDZ domain | PDZ superfamily | Protein lin-7 |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BC73 | InterPro | 225 | |||||||
| UniProtKB:Q6PC63 | InterPro | 218 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-91G3 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-231A18 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:73090 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200709 (1) | 2129 nt | ||
| Genomic | GenBank:BX537308 (1) | 191880 nt | ||
| Polypeptide | UniProtKB:A0A8M2BC73 (1) | 225 aa |
- Blanc, M., Alfonso, S., Bégout, M.L., Barrachina, C., Hyötyläinen, T., Keiter, S.H., Cousin, X. (2020) An environmentally relevant mixture of polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) disrupts mitochondrial function, lipid metabolism and neurotransmission in the brain of exposed zebrafish and their unexposed F2 offspring. The Science of the total environment. 754:142097
- Farnsworth, D.R., Saunders, L.M., Miller, A.C. (2020) A single-cell transcriptome atlas for zebrafish development. Developmental Biology. 459(2):100-108
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, L., Zuo, Z., Zhang, Y., Wu, M., Lin, J.J., Wang, C. (2014) Use of toxicogenomics to predict the potential toxic effect of Benzo(a)pyrene on zebrafish embryos: Ocular developmental toxicity. Chemosphere. 108:55-61
- Yang, X., Zou, J., Hyde, D.R., Davidson, L.A., and Wei, X. (2009) Stepwise maturation of apicobasal polarity of the neuroepithelium is essential for vertebrate neurulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(37):11426-11440
- Catalano, A.E., Raymond, P.A., Goldman, D., and Wei, X. (2007) Zebrafish dou yan mutation causes patterning defects and extensive cell death in the retina. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(5):1295-1306
- Wei, X., Luo, Y., and Hyde, D.R. (2006) Molecular cloning of three zebrafish lin7 genes and their expression patterns in the retina. Experimental Eye Research. 82(1):122-131
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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