Gene

sncb

ID
ZDB-GENE-040426-1615
Name
synuclein, beta
Symbol
sncb Nomenclature History
Previous Names
  • zgc:66343
  • zSyn-β (1)
  • zSynC (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Involved in dopaminergic neuron differentiation and larval locomotory behavior. Predicted to localize to cytoplasm. Is expressed in basal plate midbrain region; nervous system; pleuroperitoneal region; and trigeminal placode. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; Parkinson's disease 1; and Parkinson's disease 4. Orthologous to several human genes including SNCB (synuclein beta).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Milanese et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sncb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Lewy body dementia Alliance Dementia, Lewy body 127750
Associated With sncb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001058 Synuclein
Family IPR002461 Beta-synuclein
Domain Details Per Protein
Protein Length Beta-synuclein Synuclein
UniProtKB:Q7SX92 127
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-sncb monoclonal IgG1 Mouse
  • IHC
  • WB
Cell Signaling Technology, Inc.
3
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations