Gene

clcnk

ID
ZDB-GENE-040426-1379
Name
chloride channel K
Symbol
clcnk Nomenclature History
Previous Names
  • CIC-K (1)
  • clck (1)
  • zgc:64141
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Enables chloride transmembrane transporter activity. Involved in chloride ion homeostasis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in renal system. Human ortholog(s) of this gene implicated in Bartter disease type 3; Bartter disease type 4b; Gitelman syndrome; hypertension; and sensorineural hearing loss. Orthologous to human CLCNKA (chloride voltage-gated channel Ka) and CLCNKB (chloride voltage-gated channel Kb).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
22 figures from 15 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from PĂ©rez-Rius et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With clcnk Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bartter disease type 3 Alliance Bartter syndrome, type 3 607364
Bartter disease type 4b Alliance Bartter syndrome, type 4b, digenic 613090
Associated With clcnk Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000644 CBS domain
Family IPR001807 Chloride channel, voltage gated
Homologous_superfamily IPR014743 Chloride channel, core
Domain Details Per Protein
Protein Length CBS domain Chloride channel, core Chloride channel, voltage gated
UniProtKB:Q7T329 693
UniProtKB:F1QAS1 693
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-clcnk polyclonal Rabbit
  • IHC
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations