Gene
per1b
- ID
- ZDB-GENE-040419-1
- Name
- period circadian clock 1b
- Symbol
- per1b Nomenclature History
- Previous Names
-
- per4
- zfper4 (1)
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable transcription cis-regulatory region binding activity and transcription corepressor binding activity. Acts upstream of or within several processes, including dopaminergic neuron differentiation; positive regulation of dopaminergic neuron differentiation; and visual perception. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including heart; liver; muscle; ovary; and retina. Used to study attention deficit hyperactivity disorder. Orthologous to human PER1 (period circadian regulator 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 37 figures from 24 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la026125Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa21065 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21066 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31594 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41011 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa41012 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sus001Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| ulg082 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-per1b | Zebrafish Nomenclature Committee | |
| CRISPR2-per1b | He et al., 2025 |
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Human Disease
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | PAS domain | PAS domain superfamily | PAS fold-3 | Period circadian-like, C-terminal | Period circadian protein homolog 1-3, PAS-A domain | Period circadian regulator |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6E2N4 | InterPro | 1398 | ||||||
| UniProtKB:A0A8M1PH02 | InterPro | 1398 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(per1b:Luciferase) |
|
| 1 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-380L10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194797 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212439 (1) | 6777 nt | ||
| Genomic | GenBank:CR318600 (1) | 257374 nt | ||
| Polypeptide | UniProtKB:A0A8M1PH02 (1) | 1398 aa |
- He, X., Wang, Z., Cheng, L., Wang, H., Sun, Y. (2025) An antagonistic role of clock genes and lima1 in kidney regeneration. Communications biology. 8:2929
- Chaigne, C., Sapède, D., Cousin, X., Sanchou, L., Blader, P., Cau, E. (2024) Contribution of the eye and of opn4xa function to circadian photoentrainment in the diurnal zebrafish. PLoS Genetics. 20:e1011172e1011172
- Chen, M., Ouyang, Y., Yang, Y., Liu, Z., Zhao, M. (2024) Impact of sleep problems on the cardiometabolic risks: an integrated epidemiological and metabolomics study. Diabetology & metabolic syndrome. 16:267267
- Ding, H., Chen, X.C., Wan, L., Zhang, Y.Y., Rui, X.H., He, T., Liu, J., Shang, Z.B. (2024) Klebsiella pneumoniae alters zebrafish circadian rhythm via inflammatory pathways and is dependent on light cues. Heliyon. 10:e30829e30829
- Morales Fénero, C., Sacksteder, R.E., Diamos, A.G., Kimmey, J.M. (2024) Heat-inactivated Streptococcus pneumoniae augments circadian clock gene expression in zebrafish cells. Scientific Reports. 14:2780527805
- Wu, L., Zhao, M., Chen, X., Wang, H. (2024) A miR-219-5p-bmal1b negative feedback loop contributes to circadian regulation in zebrafish. Communications biology. 7:16711671
- Xu, Y., Zhang, S., Bao, Y., Luan, J., Fu, Z., Sun, M., Zhao, X., Feng, X. (2024) Melatonin protects zebrafish pancreatic development and physiological rhythms from sodium propionate-induced disturbances via the hypothalamic-pituitary-thyroid axis. Journal of the science of food and agriculture. 104(12):7454-7463
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Cao, M., Xu, T., Zhang, H., Wei, S., Wang, H., Song, Y., Guo, X., Chen, D., Yin, D. (2023) BDE-47 Causes Depression-like Effects in Zebrafish Larvae via a Non-Image-Forming Visual Mechanism. Environmental science & technology. 57(26):9592-9602
- Chen, A.Q., Xue, M., Qiu, C.Z., Zhang, H.Y., Zhou, R., Zhang, L., Yin, Z.J., Ren, D.L. (2023) Circadian clock1a coordinates neutrophil recruitment via nfe212a/duox-reactive oxygen species pathway in zebrafish. Cell Reports. 42:113179113179
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