Gene
tlr4bb
- ID
- ZDB-GENE-040219-9
- Name
- toll-like receptor 4b, duplicate b
- Symbol
- tlr4bb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have signaling receptor activity. Involved in positive regulation of hematopoietic progenitor cell differentiation. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetes mellitus (multiple); eye disease (multiple); lung disease (multiple); and vasculitis (multiple). Is expressed in several structures, including blood; forebrain neural keel; nervous system; neural rod; and yolk syncytial layer. Orthologous to human TLR4 (toll like receptor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu723 (1 image)
- eu724 (23 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from He et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000157 | Toll/interleukin-1 receptor homology (TIR) domain |
| Family | IPR017241 | Toll-like receptor |
| Homologous_superfamily | IPR032675 | Leucine-rich repeat domain superfamily |
| Homologous_superfamily | IPR035897 | Toll/interleukin-1 receptor homology (TIR) domain superfamily |
| Repeat | IPR001611 | Leucine-rich repeat |
| Repeat | IPR003591 | Leucine-rich repeat, typical subtype |
Domain Details Per Protein
| Protein | Length | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | Toll/interleukin-1 receptor homology (TIR) domain | Toll/interleukin-1 receptor homology (TIR) domain superfamily | Toll-like receptor |
|---|---|---|---|---|---|---|---|
|
UniProtKB:B8A691
|
819 | ||||||
|
UniProtKB:Q6TS41
|
819 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
tlr4bb-201
(1)
|
Havana | 2736 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- Authors in Sullivan C et al (ZDB-PUB-091023-26) state: "The strong conclusion from the analysis of conserved syntenies is that the zebrafish genes called tlr4a and tlr4b are not orthologs of the human TLR4 gene, but represent a reciprocal loss of ohnologs derived from the second round of genome duplication at about the time of the vertebrate radiation. The implication of orthology can be avoided where none exists by calling the zebrafish genes tlr4ba and tlr4bb, and the human gene TLR4A.