PUBLICATION
Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates
- Authors
- He, Q., Zhang, C., Wang, L., Zhang, P., Ma, D., Lv, J., Liu, F.
- ID
- ZDB-PUB-141230-19
- Date
- 2015
- Source
- Blood 125(7): 1098-106 (Journal)
- Registered Authors
- Liu, Feng, Ma, Dongyuan, Wang, Lu, Zhang, Chunxia, Zhang, Panpan
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Cell Differentiation/drug effects
- Embryo, Mammalian
- Embryo, Nonmammalian
- Hematopoiesis/drug effects
- Hematopoiesis/physiology*
- Hematopoietic Stem Cells/drug effects*
- Hematopoietic Stem Cells/physiology*
- Inflammation/metabolism
- Inflammation Mediators/pharmacology
- Inflammation Mediators/physiology*
- Male
- Mice
- NF-kappa B/metabolism
- Signal Transduction/immunology
- Toll-Like Receptor 4/metabolism
- Zebrafish
- PubMed
- 25540193 Full text @ Blood
Citation
He, Q., Zhang, C., Wang, L., Zhang, P., Ma, D., Lv, J., Liu, F. (2015) Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates. Blood. 125(7):1098-106.
Abstract
Inflammatory signaling has been shown essential for stress hematopoiesis in adult bone marrow, either through increasing proliferation or by directing differentiation of hematopoietic stem and progenitor cells (HSPCs) towards myeloid or lymphoid lineages. However, its role in embryonic normal hematopoiesis has been unknown. Here, we demonstrate that in both zebrafish and mouse embryos, inflammatory signaling is necessary and sufficient for HSPC emergence, in the absence of infection or pathological inflammation. Mechanistically, inflammatory signaling regulates hemogenic endothelium-derived HSPC development through a conserved TLR-NFκB core signaling, which then promotes Notch activity, a well-known signal required for HSPC specification in vertebrates. Our findings establish a previously unrecognized link between inflammatory signaling and HSPC emergence, and provide new insights into regenerative medicine and novel therapies to treat innate immune-related diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping