Gene
cyp17a1
- ID
- ZDB-GENE-040213-2
- Name
- cytochrome P450, family 17, subfamily A, polypeptide 1
- Symbol
- cyp17a1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity and steroid 17-alpha-monooxygenase activity. Acts upstream of or within with a positive effect on female sex determination. Acts upstream of or within with a negative effect on male sex determination. Acts upstream of or within androst-4-ene-3,17-dione biosynthetic process and progesterone metabolic process. Is expressed in brain and endocrine system. Human ortholog(s) of this gene implicated in several diseases, including cholelithiasis; congenital adrenal hyperplasia; gallbladder cancer; osteoporosis; and prostate cancer. Orthologous to human CYP17A1 (cytochrome P450 family 17 subfamily A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 36 figures from 26 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7157435 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital adrenal hyperplasia | Alliance | 17,20-lyase deficiency, isolated | 202110 |
| congenital adrenal hyperplasia | Alliance | 17-alpha-hydroxylase/17,20-lyase deficiency | 202110 |
1 - 2 of 2
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:B3DH80 | InterPro PDB | 519 | ||||
| UniProtKB:A0A8M1PIC7 | InterPro PDB | 519 |
1 - 2 of 2
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp17a1-201
(1)
|
Ensembl | 2,799 nt |
1 - 1 of 1
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cyp17a1 | Rabbit |
|
3 |
1 - 1 of 1
Plasmids
No data available