ZFIN is now using GRCz12tu for Genomic Data
Gene
pdzk1
- ID
- ZDB-GENE-031222-1
- Name
- PDZ domain containing 1
- Symbol
- pdzk1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable protein-membrane adaptor activity and signaling receptor binding activity. Predicted to be involved in protein localization to plasma membrane. Predicted to be active in apical plasma membrane. Is expressed in gut; intestinal bulb; pronephric duct; pronephric proximal convoluted tubule; and pronephric proximal straight tubule. Orthologous to human PDZK1 (PDZ domain containing 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1074 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Xie et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027099Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| uom2 | Allele with one insertion | Exon 2 | Premature Stop | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Na+/H+ exchange regulatory cofactor | PDZ domain | PDZ superfamily |
|---|---|---|---|---|---|
| UniProtKB:F1QTX0 | InterPro | 553 | |||
| UniProtKB:Q08BE7 | InterPro | 559 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-390B10 | ZFIN Curated Data | |
| Contained in | Fosmid | CH1073-237F15 | ZFIN Curated Data | |
| Encodes | EST | cb1074 | Thisse et al., 2001 | |
| Encodes | EST | fa55e12 | ZFIN Curated Data | |
| Encodes | EST | fb65e01 | ||
| Encodes | EST | IMAGE:6959990 | ||
| Encodes | cDNA | MGC:195334 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128670 (1) | 2313 nt | ||
| Genomic | GenBank:CU695204 (2) | 117574 nt | ||
| Polypeptide | UniProtKB:Q08BE7 (1) | 559 aa |
- Xiao, Y., Miao, Z., Sun, J., Xing, W., Wei, Y., Bai, J., Ye, H., Si, Y., Cai, L. (2023) Allisartan Isoproxil Promotes Uric Acid Excretion by Interacting with Intestinal Urate Transporters in Hyperuricemic Zebrafish (Danio rerio). Bulletin of experimental biology and medicine. 175(5):638-643
- Cao, M., Wang, N., Yan, X., Yang, N., Fu, Q., Zhang, X., Zhang, Y., Li, C. (2022) Structures, evolutionary relationships and expression profiles of the tumour necrosis factor superfamily and their receptors in black rockfish (Sebastes schlegelii). Developmental and comparative immunology. 132:104405
- Xie, J., Jusuf, P.R., Bui, B.V., Dudczig, S., Sztal, T.E., Goodbourn, P.T. (2021) Altered Visual Function in a Larval Zebrafish Knockout of Neurodevelopmental Risk Gene pdzk1. Investigative ophthalmology & visual science. 62:29
- Sander, V., Salleh, L., Naylor, R.W., Schierding, W., Sontam, D.M., O'Sullivan, J.M., Davidson, A.J. (2019) Transcriptional profiling of the zebrafish proximal tubule. American journal of physiology. Renal physiology. 317(2):F478-F488
- Barrodia, P., Patra, C., Swain, R.K. (2018) EF-hand domain containing 2 (Efhc2) is crucial for distal segmentation of pronephros in zebrafish. Cell & Bioscience. 8:53
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Webb, K.J., Norton, W.H.J., Trumbach, D., Meijer, A.H., Ninkovic, J., Topp, S., Heck, D., Marr, C., Wurst, W., Theis, F.J., Spaink, H.P., and Bally-Cuif, L. (2009) Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine. Genome biology. 10(7):R81
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Wingert, R.A., Selleck, R., Yu, J., Song, H.D., Chen, Z., Song, A., Zhou, Y., Thisse, B., Thisse, C., McMahon, A.P., and Davidson, A.J. (2007) The cdx Genes and Retinoic Acid Control the Positioning and Segmentation of the Zebrafish Pronephros. PLoS Genetics. 3(10):1922-1938
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