Gene
smox
- ID
- ZDB-GENE-031201-3
- Name
- spermine oxidase
- Symbol
- smox Nomenclature History
- Previous Names
-
- cb1027 (1)
- wu:fq32f10
- zgc:77167
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable polyamine oxidase activity. Acts upstream of or within hemopoiesis. Predicted to be located in peroxisome. Predicted to be active in cytoplasm. Is expressed in several structures, including anterior axial hypoblast; blood vessel; mesoderm; nervous system; and pancreatic system. Orthologous to human SMOX (spermine oxidase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1027 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Tijssen et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| um66 | Allele with one deletion | Unknown | Frameshift, Premature Stop | zinc finger nuclease | |
| um67 | Allele with one deletion | Unknown | Frameshift, Premature Stop | zinc finger nuclease | |
| zko792a | Allele with one insertion | Unknown | Unknown | CRISPR | |
| zko792b | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-smox | (2) | |
| CRISPR2-smox | Herzog et al., 2020 | |
| MO1-smox | N/A | Tijssen et al., 2011 |
| MO2-smox | N/A | Lai et al., 2024 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Amine oxidase | FAD/NAD(P)-binding domain superfamily | Flavin monoamine oxidase and related enzymes |
|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z453 | InterPro | 326 | |||
| UniProtKB:B8A458 | InterPro | 539 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-8F21 | ZFIN Curated Data | |
| Encodes | EST | cb1027 | Thisse et al., 2001 | |
| Encodes | EST | fq32f10 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:55767 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77167 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192141 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001328186 (1) | 2220 nt | ||
| Genomic | GenBank:BX004888 (1) | 230724 nt | ||
| Polypeptide | UniProtKB:B8A458 (1) | 539 aa |
- Lai, S., Shiraishi, H., Sebastian, W.A., Shimizu, N., Umeda, R., Ikeuchi, M., Kiyota, K., Takeno, T., Miyazaki, S., Yano, S., Shimada, T., Yoshimura, A., Hanada, R., Hanada, T. (2024) Effect of nonsense-mediated mRNA decay factor SMG9 deficiency on premature aging in zebrafish. Communications biology. 7:654654
- Herzog, C., Greenald, D., Larraz, J., Keatinge, M., Herrgen, L. (2020) RNA-seq analysis and compound screening highlight multiple signalling pathways regulating secondary cell death after acute CNS injury in vivo. Biology Open. 9(5):
- Menon, T., Borbora, A.S., Kumar, R., Nair, S. (2020) Dynamic optima in cell sizes during early development enable normal gastrulation in zebrafish embryos. Developmental Biology. 468(1-2):26-40
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Wong, Q.W., Sun, M.A., Lau, S.W., Parsania, C., Zhou, S., Zhong, S., Ge, W. (2017) Identification and characterization of a specific 13-miRNA expression signature during follicle activation in the zebrafish ovary. Biology of reproduction. 98(1):42-53
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kok, F.O., Shin, M., Ni, C., Gupta, A., Grosse, A.S., van Impel, A., Kirchmaier, B.C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S.A., Lawson, N.D. (2015) Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Developmental Cell. 32(1):97-108
- Varshney, G.K., Zhang, S., Gildea, D.E., Wolfsberg, T.G., and Burgess, S.M. (2013) The Zebrafish Insertion Collection (ZInC): a web based, searchable collection of zebrafish mutations generated by DNA insertion. Nucleic acids research. 41(D1):D861-864
- Gomez, G., Lee, J.H., Veldman, M.B., Lu, J., Xiao, X., and Lin, S. (2012) Identification of Vascular and Hematopoietic Genes Downstream of etsrp by Deep Sequencing in Zebrafish. PLoS One. 7(3):e31658
- Tijssen, M.R., Cvejic, A., Joshi, A., Hannah, R.L., Ferreira, R., Forrai, A., Bellissimo, D.C., Oram, S.H., Smethurst, P.A., Wilson, N.K., Wang, X., Ottersbach, K., Stemple, D.L., Green, A.R., Ouwehand, W.H., and Göttgens, B. (2011) Genome-wide Analysis of Simultaneous GATA1/2, RUNX1, FLI1, and SCL Binding in Megakaryocytes Identifies Hematopoietic Regulators. Developmental Cell. 20(5):597-609
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