ZFIN is now using GRCz12tu for Genomic Data
Gene
ntf3
- ID
- ZDB-GENE-031118-66
- Name
- neurotrophin 3
- Symbol
- ntf3 Nomenclature History
- Previous Names
-
- NT-3 (1)
- ntf3-pen
- wu:fl98d04
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable growth factor activity and nerve growth factor receptor binding activity. Acts upstream of or within negative regulation of programmed cell death and peripheral nervous system development. Predicted to be located in extracellular region and membrane. Predicted to be active in several cellular components, including axon; dendrite; and synaptic vesicle. Is expressed in several structures, including brain; cardiovascular system; kidney; otic placode; and retina. Human ortholog(s) of this gene implicated in Alzheimer's disease and asthma. Orthologous to human NTF3 (neurotrophin 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | Nerve growth factor conserved site | Nerve growth factor-like | Nerve growth factor-related | Neurotrophin-3 | Neutrophin-3, N-terminal |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1P3S4 | InterPro | 256 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-ntf3 | polyclonal | IgG | Rabbit |
|
Thermo Fisher Scientific (Lab Vision)
|
2 |
Plasmids
No data available
- Genome Browsers