Gene
erbb2
- ID
- ZDB-GENE-031118-121
- Name
- erb-b2 receptor tyrosine kinase 2
- Symbol
- erbb2 Nomenclature History
- Previous Names
-
- wu:fv70f10
- zgc:63601
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have transmembrane receptor protein tyrosine kinase activity. Involved in animal organ development; fin regeneration; and nervous system development. Predicted to localize to basal plasma membrane; integral component of plasma membrane; and receptor complex. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; malignant glioma; mammary Paget's disease; prostate cancer; and urinary system cancer (multiple). Is expressed in several structures, including anterior segment eye; cranial ganglion; fin; heart; and primary neurons. Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 11 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| lung cancer | Alliance | Adenocarcinoma of lung, somatic | 211980 |
| ovarian cancer | Alliance | Ovarian cancer, somatic | 167000 |
| stomach cancer | Alliance | Gastric cancer, somatic | 613659 |
| Glioblastoma, somatic | 137800 | ||
| ?Visceral neuropathy, familial, 2, autosomal recessive | 619465 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000494 | Receptor L-domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR006211 | Furin-like cysteine-rich domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR032778 | Growth factor receptor domain 4 |
| Domain | IPR049328 | Epidermal growth factor receptor-like, transmembrane-juxtamembrane segment |
| Family | IPR016245 | Tyrosine protein kinase, EGF/ERB/XmrK receptor |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR036941 | Receptor L-domain superfamily |
| Homologous_superfamily | IPR044912 | Epidermal growth factor receptor, juxtamembrane domain |
| Repeat | IPR006212 | Furin-like repeat |
Domain Details Per Protein
| Protein | Length | Epidermal growth factor receptor, juxtamembrane domain | Epidermal growth factor receptor-like, transmembrane-juxtamembrane segment | Furin-like cysteine-rich domain | Furin-like repeat | Growth factor receptor cysteine-rich domain superfamily | Growth factor receptor domain 4 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor L-domain | Receptor L-domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine protein kinase, EGF/ERB/XmrK receptor |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5EBY4
|
1275 |
Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-erbb2 | polyclonal | IgG | Rabbit |
|
EMD Chemicals Inc., an Affiliate of Merck KGaA
|
2 |
Plasmids
No data available