Gene
cyc1
- ID
- ZDB-GENE-031105-2
- Name
- cytochrome c-1
- Symbol
- cyc1 Nomenclature History
- Previous Names
-
- fb80h03
- im:6911272
- sr:nyz104
- wu:fb80h03
- zgc:123089
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable heme binding activity; metal ion binding activity; and ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex III. Is expressed in several structures, including adaxial cell; digestive system; eye; midbrain; and musculature system. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 6. Orthologous to human CYC1 (cytochrome c1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6911272 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
mitochondrial complex III deficiency nuclear type 6 | Alliance | Mitochondrial complex III deficiency, nuclear type 6 | 615453 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Cytochrome c1 | Cytochrome c1, transmembrane anchor, C-terminal | Cytochrome c-like domain | Cytochrome c-like domain superfamily |
---|---|---|---|---|---|---|
UniProtKB:Q3B7R0 | InterPro | 307 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-231H5 | ZFIN Curated Data | |
Encodes | EST | fb80h03 | ||
Encodes | EST | fz41g09 | ZFIN Curated Data | |
Encodes | EST | IMAGE:6911272 | ||
Encodes | EST | nyz104 | ZFIN Curated Data | |
Encodes | cDNA | MGC:123089 | ZFIN Curated Data | |
Encodes | cDNA | MGC:162442 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001037393 (1) | 1387 nt | ||
Genomic | GenBank:BX649289 (1) | 124708 nt | ||
Polypeptide | UniProtKB:Q3B7R0 (1) | 307 aa |
Species | Symbol | Chromosome | Accession # | Evidence |
---|---|---|---|---|
Human | CYC1 | 8 | Amino acid sequence comparison (1) |
- Shi, L., Zhang, A., Liu, H., Wang, H. (2023) Deletion of the foxO4 Gene Increases Hypoxia Tolerance in Zebrafish. International Journal of Molecular Sciences. 24(10):
- Tian, J., Du, Y., Yu, E., Lei, C., Xia, Y., Jiang, P., Li, H., Zhang, K., Li, Z., Gong, W., Xie, J., Wang, G. (2022) Prostaglandin 2α Promotes Autophagy and Mitochondrial Energy Production in Fish Hepatocytes. Cells. 11(12)
- Sun, C.C., Zhou, Z.Q., Chen, Z.L., Zhu, R.K., Yang, D., Peng, X.Y., Zheng, L., Tang, C.F. (2021) Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish. Biology. 10(8):
- Boswell, M., Boswell, W., Lu, Y., Savage, M., Walter, R.B. (2020) Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Scientific Reports. 10:3321
- Zhou, Z., Zheng, L., Tang, C., Chen, Z., Zhu, R., Peng, X., Wu, X., Zhu, P. (2020) Identification of Potentially Relevant Genes for Excessive Exercise-Induced Pathological Cardiac Hypertrophy in Zebrafish. Frontiers in Physiology. 11:565307
- Li, X., Zhang, B., Li, N., Ji, X., Liu, K., Jin, M. (2019) Zebrafish neurobehavioral phenomics applied as the behavioral warning methods for fingerprinting endocrine disrupting effect by lead exposure at environmentally relevant level. Chemosphere. 231:315-325
- Pradhan, A., Bereketoglu, C., Martin, L., Duhagon, J., Olsson, P.E. (2019) The food preservative ethoxyquin impairs zebrafish development, behavior and alters gene expression profile. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 135:110926
- Cao, F., Wu, P., Huang, L., Li, H., Qian, L., Pang, S., Qiu, L. (2018) Short-term developmental effects and potential mechanisms of azoxystrobin in larval and adult zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 198:129-140
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Cal, L., MegÍas, M., Cerdá-Reverter, J.M., Postlethwait, J.H., Braasch, I., Rotllant, J. (2017) BAC Recombineering of the Agouti Loci from Spotted Gar and Zebrafish Reveals the Evolutionary Ancestry of Dorsal-Ventral Pigment Asymmetry in Fish. Journal of experimental zoology. Part B, Molecular and developmental evolution. 328(7):697-708
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