Gene

egfra

ID
ZDB-GENE-030918-1
Name
epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
Symbol
egfra Nomenclature History
Previous Names
  • egfr
  • erbb1a (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Is predicted to enable epidermal growth factor binding activity and epidermal growth factor-activated receptor activity. Involved in several processes, including positive regulation of epithelial cell proliferation; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Acts upstream of or within blood vessel lumenization. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Is expressed in several structures, including gill; liver; nervous system; pleuroperitoneal region; and somite. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With egfra Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
lung cancer Alliance Adenocarcinoma of lung, response to tyrosine kinase inhibitor in 211980
lung cancer Alliance Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in 211980
lung cancer Alliance {Nonsmall cell lung cancer, susceptibility to} 211980
?Inflammatory skin and bowel disease, neonatal, 2 616069
Associated With egfra Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000494 Receptor L-domain
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR006211 Furin-like cysteine-rich domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR032778 Growth factor receptor domain 4
Family IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR036941 Receptor L-domain superfamily
Repeat IPR006212 Furin-like repeat
Domain Details Per Protein
Protein Length Furin-like cysteine-rich domain Furin-like repeat Growth factor receptor cysteine-rich domain superfamily Growth factor receptor domain 4 Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Receptor L-domain Receptor L-domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine protein kinase, EGF/ERB/XmrK receptor
UniProtKB:B3DK54 1191
UniProtKB:F1R671 760
UniProtKB:Q6QMR7 503
UniProtKB:Q7SZF7 1191
UniProtKB:F1RA48 389
UniProtKB:F1Q7X2 625
UniProtKB:Q6QMR8 389
UniProtKB:Q6QMR6 625
UniProtKB:Q6VQA3 1191
UniProtKB:A0A0R4IFV9 1191
UniProtKB:F1RBY7 503
UniProtKB:F1QU74 243
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations