Gene
egfra
- ID
- ZDB-GENE-030918-1
- Name
- epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
- Symbol
- egfra Nomenclature History
- Previous Names
-
- egfr
- erbb1a (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable epidermal growth factor binding activity and epidermal growth factor receptor activity. Involved in regulation of circadian sleep/wake cycle, sleep. Acts upstream of or within blood vessel lumenization. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in basal plasma membrane. Is expressed in several structures, including gill; liver; nervous system; pleuroperitoneal region; and somite. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; lung non-small cell carcinoma (multiple); pancreatic cancer; prostate cancer; and pulmonary tuberculosis. Orthologous to human EGFR (epidermal growth factor receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| lung cancer | Alliance | Adenocarcinoma of lung, response to tyrosine kinase inhibitor in | 211980 |
| lung cancer | Alliance | Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in | 211980 |
| lung cancer | Alliance | {Nonsmall cell lung cancer, susceptibility to} | 211980 |
| ?Inflammatory skin and bowel disease, neonatal, 2 | 616069 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000494 | Receptor L-domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR006211 | Furin-like cysteine-rich domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR032778 | Growth factor receptor domain 4 |
| Family | IPR016245 | Tyrosine protein kinase, EGF/ERB/XmrK receptor |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR036941 | Receptor L-domain superfamily |
| Homologous_superfamily | IPR044912 | Epidermal growth factor receptor, juxtamembrane domain |
| Repeat | IPR006212 | Furin-like repeat |
Domain Details Per Protein
| Protein | Length | Epidermal growth factor receptor, juxtamembrane domain | Furin-like cysteine-rich domain | Furin-like repeat | Growth factor receptor cysteine-rich domain superfamily | Growth factor receptor domain 4 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor L-domain | Receptor L-domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine protein kinase, EGF/ERB/XmrK receptor |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IFV9
|
1191 | ||||||||||||||
|
UniProtKB:Q6QMR8
|
389 | ||||||||||||||
|
UniProtKB:Q6QMR6
|
625 | ||||||||||||||
|
UniProtKB:F1Q7X2
|
625 | ||||||||||||||
|
UniProtKB:F1RA48
|
389 | ||||||||||||||
|
UniProtKB:B3DK54
|
1191 | ||||||||||||||
|
UniProtKB:Q6QMR7
|
503 | ||||||||||||||
|
UniProtKB:F1QU74
|
243 | ||||||||||||||
|
UniProtKB:Q7SZF7
|
1191 | ||||||||||||||
|
UniProtKB:F1RBY7
|
503 | ||||||||||||||
|
UniProtKB:Q6VQA3
|
1191 | ||||||||||||||
|
UniProtKB:F1R671
|
760 |
Interactions and Pathways
Plasmids
No data available