Gene
aifm1
- ID
- ZDB-GENE-030826-11
- Name
- apoptosis inducing factor mitochondrion associated 1
- Symbol
- aifm1 Nomenclature History
- Previous Names
-
- AIF
- pdcd8
- zgc:91994
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable FAD binding activity and NAD(P)H oxidase H2O2-forming activity. Predicted to be involved in apoptotic process and mitochondrial disulfide relay system. Predicted to be located in mitochondrial envelope; nucleus; and perinuclear region of cytoplasm. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; digestive system; hatching gland; musculature system; and polster. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined oxidative phosphorylation deficiency 6. Orthologous to human AIFM1 (apoptosis inducing factor mitochondria associated 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7157541 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-aifm1 | Martínez-Morcillo et al., 2021 | |
| CRISPR2-aifm1 | Lin et al., 2025 | |
| CRISPR3-aifm1 | Lin et al., 2025 | |
| CRISPR4-aifm1 | Lin et al., 2025 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-Tooth disease X-linked recessive 4 | Alliance | Cowchock syndrome | 310490 |
| combined oxidative phosphorylation deficiency 6 | Alliance | Combined oxidative phosphorylation deficiency 6 | 300816 |
| X-linked deafness 5 | Alliance | Deafness, X-linked 5 | 300614 |
| Spondyloepimetaphyseal dysplasia, X-linked, with hypomyelinating leukodystrophy | 300232 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR023753 | FAD/NAD(P)-binding domain |
| Domain | IPR029324 | Mitochondrial apoptosis-inducing factor, C-terminal domain |
| Domain | IPR032773 | Protein MGARP, N-terminal |
| Family | IPR050446 | FAD-dependent Oxidoreductases and Apoptosis Regulators |
| Homologous_superfamily | IPR016156 | FAD/NAD-linked reductase, dimerisation domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | FAD-dependent Oxidoreductases and Apoptosis Regulators | FAD/NAD-linked reductase, dimerisation domain superfamily | FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain superfamily | Mitochondrial apoptosis-inducing factor, C-terminal domain | Protein MGARP, N-terminal |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BCB6 | InterPro | 748 | ||||||
| UniProtKB:Q5XFY2 | InterPro | 613 | ||||||
| UniProtKB:A0A8M3AS24 | InterPro | 621 | ||||||
| UniProtKB:A0A8M2BCF4 | InterPro | 740 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-103E21 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7157541 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:91994 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_200102 (1) | 2450 nt | ||
| Genomic | GenBank:BX470076 (1) | 112637 nt | ||
| Polypeptide | UniProtKB:A0A8M2BCB6 (1) | 748 aa |
- Gui, W., Wang, W.X. (2024) Cu(II)-Dependent Spine Development Injury in Zebrafish (Danio rerio) with Organ Heterogeneous Cu Imbalance. Environmental science & technology. 58(42):18578-18588
- Cao, L., Fang, H., Yan, D., Wu, X.M., Zhang, J., Chang, M.X. (2022) CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. Communications biology. 5:889
- Li, Y., Chen, Q., Liu, Y., Bi, L., Jin, L., Xu, K., Peng, R. (2022) High glucose-induced ROS-accumulation in embryo-larval stages of zebrafish leads to mitochondria-mediated apoptosis. Apoptosis : an international journal on programmed cell death. 27(7-8):509-520
- Martínez-Morcillo, F.J., Cantón-Sandoval, J., Martínez-Navarro, F.J., Cabas, I., Martínez-Vicente, I., Armistead, J., Hatzold, J., López-Muñoz, A., Martínez-Menchón, T., Corbalán-Vélez, R., Lacal, J., Hammerschmidt, M., García-Borrón, J.C., García-Ayala, A., Cayuela, M.L., Pérez-Oliva, A.B., García-Moreno, D., Mulero, V. (2021) NAMPT-derived NAD+ fuels PARP1 to promote skin inflammation through parthanatos cell death. PLoS Biology. 19:e3001455
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Qi, Z., Yan, D., Cao, L., Xu, Y., Chang, M. (2021) Zebrafish BID Exerts an Antibacterial Role by Negatively Regulating p53, but in a Caspase-8-Independent Manner. Frontiers in immunology. 12:707426
- Qiang, L., Cheng, J. (2021) Exposure to polystyrene microplastics impairs gonads of zebrafish (Danio rerio). Chemosphere. 263:128161
- Félix, L.M., Luzio, A., Antunes, L., Coimbra, A.M., Valentim, A. (2020) Malformations and mortality in zebrafish early stages associated with elevated caspase activity after 24 h exposure to MS-222. Toxicology and applied pharmacology. 412:115385
- Félix, L.M., Luzio, A., Santos, A., Antunes, L., Coimbra, A.M., Valentim, A. (2020) MS-222 induces biochemical and transcriptional changes related to oxidative stress, cell proliferation and apoptosis in zebrafish embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 237:108834
- Huang, L., Urasaki, A., Inagaki, N. (2019) Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons in the zebrafish brain. Scientific Reports. 9:1799
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