Gene

adam8a

ID

ZDB-GENE-030616-622

Name

ADAM metallopeptidase domain 8a

Symbol

adam8a Nomenclature History

Previous Names

adam8
CD156a (1)
si:zc217g15.7
zgc:64059

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Exhibits metallopeptidase activity and protease binding activity. Predicted to be involved in integrin-mediated signaling pathway and proteolysis. Predicted to localize to integral component of membrane. Is expressed in several structures, including axial vasculature; intermediate cell mass of mesoderm; macrophage; tail bud; and yolk. Orthologous to human ADAM8 (ADAM metallopeptidase domain 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:64059 (1 image)
IMAGE:7148247 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Iida et al., 2010
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adam8a Human Ortholog

No data available

Associated With adam8a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018358	Disintegrin, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001590	Peptidase M12B, ADAM/reprolysin
Domain	IPR001762	Disintegrin domain
Domain	IPR002870	Peptidase M12B, propeptide
Domain	IPR006586	ADAM, cysteine-rich domain
Domain	IPR013111	EGF-like domain, extracellular
Domain	IPR034027	Reprolysin domain, adamalysin-type
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily
Homologous_superfamily	IPR036436	Disintegrin domain superfamily

Domain Details Per Protein

Protein	Length	ADAM, cysteine-rich domain	Disintegrin, conserved site	Disintegrin domain	Disintegrin domain superfamily	EGF-like domain	EGF-like domain, extracellular	Metallopeptidase, catalytic domain superfamily	Peptidase M12B, ADAM/reprolysin	Peptidase M12B, propeptide	Reprolysin domain, adamalysin-type
UniProtKB:Q7ZYZ9 InterPro	843

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	adam8a-201 (1) Ensembl	Havana	3251 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	adam8a-002 (1) Ensembl	Havana	650 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations