Gene

ptenb

ID
ZDB-GENE-030616-47
Name
phosphatase and tensin homolog B
Symbol
ptenb Nomenclature History
Previous Names
  • pten
  • fa11a08
  • fb73f10
  • fc83f12
  • fd16b10
  • fk90e11
  • si:bz1g13.4
  • wu:fa11a08
  • wu:fb73f10
  • wu:fc83f12
  • wu:fd16b10
  • wu:fk90e11
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Exhibits lipid phosphatase activity. Involved in several processes, including lifelong otolith mineralization; phosphatidylinositol dephosphorylation; and regulation of protein kinase B signaling. Predicted to localize to PML body and cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome; PTEN hamartoma tumor syndrome; breast cancer (multiple); macrocephaly-autism syndrome; and nervous system cancer (multiple). Is expressed in several structures, including adaxial cell; nervous system; neural rod; pectoral fin; and pharyngeal arch. Orthologous to human PTEN (phosphatase and tensin homolog).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ptenb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bannayan-Riley-Ruvalcaba syndrome Alliance Cowden syndrome 1 158350
Bannayan-Riley-Ruvalcaba syndrome Alliance Lhermitte-Duclos disease 158350
macrocephaly-autism syndrome Alliance Macrocephaly/autism syndrome 605309
prostate cancer Alliance Prostate cancer, somatic 176807
{Glioma susceptibility 2} 613028
{Meningioma} 607174
Associated With ptenb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR016130 Protein-tyrosine phosphatase, active site
Domain IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
Domain IPR000387 Tyrosine-specific protein phosphatases domain
Domain IPR003595 Protein-tyrosine phosphatase, catalytic
Domain IPR014020 Tensin phosphatase, C2 domain
Domain IPR029023 Tensin-type phosphatase domain
Domain IPR045101 PTEN, phosphatase domain
Family IPR017361 Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
Homologous_superfamily IPR029021 Protein-tyrosine phosphatase-like
Homologous_superfamily IPR035892 C2 domain superfamily
Domain Details Per Protein
Protein Length Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN C2 domain superfamily Protein-tyrosine phosphatase, active site Protein-tyrosine phosphatase, catalytic Protein-tyrosine phosphatase-like PTEN, phosphatase domain Tensin phosphatase, C2 domain Tensin-type phosphatase domain Tyrosine-specific protein phosphatase, PTPase domain Tyrosine-specific protein phosphatases domain
UniProtKB:Q7ZZ56 399
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations