Gene

stat1b

ID

ZDB-GENE-030616-23

Name

signal transducer and activator of transcription 1b

Symbol

stat1b Nomenclature History

Previous Names

si:by134g18.3
si:by51f19.2
si:dz199m19.2
si:dz73o4.3
si:dz87i4.1
si:xx-51f19.2
wu:fi49f02

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hemopoiesis. Predicted to be located in nucleoplasm. Predicted to be part of ISGF3 complex. Predicted to be active in cytoplasm and nucleus. Is expressed in cardiovascular system; eye; intermediate cell mass of mesoderm; kidney; and lateral plate mesoderm. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); breast cancer (multiple); immunodeficiency 31A; immunodeficiency 31B; and immunodeficiency 31C. Orthologous to human STAT1 (signal transducer and activator of transcription 1).

Genome Resources

Note

novel protein similar to human signal transduction and activator of transcription 1 (STAT1)

Comparative Information

Expression

All Expression Data

21 figures from 15 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Song et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With stat1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
chronic mucocutaneous candidiasis	Alliance	Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant	614162
immunodeficiency 31A	Alliance	Immunodeficiency 31A, mycobacteriosis, autosomal dominant	614892
immunodeficiency 31B	Alliance	Immunodeficiency 31B, mycobacterial and viral infections, autosomal recessive	613796
immunodeficiency 31C	Alliance	Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant	614162

Associated With stat1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000980	SH2 domain
Domain	IPR013799	STAT transcription factor, protein interaction
Domain	IPR013800	STAT transcription factor, all-alpha domain
Domain	IPR013801	STAT transcription factor, DNA-binding
Domain	IPR048988	Signal transducer and activator of transcription, linker domain
Family	IPR001217	Transcription factor STAT
Homologous_superfamily	IPR008967	p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily	IPR012345	STAT transcription factor, DNA-binding, N-terminal
Homologous_superfamily	IPR015988	STAT transcription factor, coiled coil
Homologous_superfamily	IPR036535	STAT transcription factor, N-terminal domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M3B5U5	InterPro	708
UniProtKB:A0A8M9QF99	InterPro	634
UniProtKB:A0A8M9PRY3	InterPro	609
UniProtKB:A0A8M9Q4I2	InterPro	438
UniProtKB:A0A8M9QAL7	InterPro	683
UniProtKB:A0A8M9QJJ2	InterPro	640
UniProtKB:B0S789	InterPro	725

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ottdart00000001761 (1)	Havana	682 nt	Select Tool ZFIN BLAST
mRNA	ottdart00000001848 (1)	Havana	1,706 nt	Select Tool ZFIN BLAST
mRNA	ottdart00000056007 (1)	Havana	1,527 nt	Select Tool ZFIN BLAST
mRNA	stat1b-201 (1) Ensembl	Ensembl	4,113 nt	Select Tool ZFIN BLAST
mRNA	stat1b-202 (1) Ensembl	Ensembl	535 nt	Select Tool ZFIN BLAST
mRNA	stat1b-204 (1) Ensembl	Ensembl	3,189 nt	Select Tool ZFIN BLAST
ncRNA	stat1b-003 (1) Ensembl	Ensembl	363 nt	Select Tool ZFIN BLAST
ncRNA	stat1b-004 (1) Ensembl	Ensembl	812 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations