Gene
stat1b
- ID
- ZDB-GENE-030616-23
- Name
- signal transducer and activator of transcription 1b
- Symbol
- stat1b Nomenclature History
- Previous Names
-
- si:by134g18.3
- si:by51f19.2
- si:dz199m19.2
- si:dz73o4.3
- si:dz87i4.1
- si:xx-51f19.2
- wu:fi49f02
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within hemopoiesis. Predicted to be located in nucleoplasm. Predicted to be part of ISGF3 complex. Predicted to be active in cytoplasm and nucleus. Is expressed in cardiovascular system; eye; intermediate cell mass of mesoderm; kidney; and lateral plate mesoderm. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); breast cancer (multiple); immunodeficiency 31A; immunodeficiency 31B; and immunodeficiency 31C. Orthologous to human STAT1 (signal transducer and activator of transcription 1).
- Genome Resources
- Note
-
novel protein similar to human signal transduction and activator of transcription 1 (STAT1)
- Comparative Information
-
- All Expression Data
- 21 figures from 15 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Song et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
chronic mucocutaneous candidiasis | Alliance | Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant | 614162 |
immunodeficiency 31A | Alliance | Immunodeficiency 31A, mycobacteriosis, autosomal dominant | 614892 |
immunodeficiency 31B | Alliance | Immunodeficiency 31B, mycobacterial and viral infections, autosomal recessive | 613796 |
immunodeficiency 31C | Alliance | Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant | 614162 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000980 | SH2 domain |
Domain | IPR013799 | STAT transcription factor, protein interaction |
Domain | IPR013800 | STAT transcription factor, all-alpha domain |
Domain | IPR013801 | STAT transcription factor, DNA-binding |
Domain | IPR048988 | Signal transducer and activator of transcription, linker domain |
Family | IPR001217 | Transcription factor STAT |
Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
Homologous_superfamily | IPR012345 | STAT transcription factor, DNA-binding, N-terminal |
Homologous_superfamily | IPR015988 | STAT transcription factor, coiled coil |
Homologous_superfamily | IPR036535 | STAT transcription factor, N-terminal domain superfamily |
Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
Protein | Additional Resources | Length | p53-like transcription factor, DNA-binding domain superfamily | SH2 domain | SH2 domain superfamily | Signal transducer and activator of transcription, linker domain | STAT transcription factor, all-alpha domain | STAT transcription factor, coiled coil | STAT transcription factor, DNA-binding | STAT transcription factor, DNA-binding, N-terminal | STAT transcription factor, N-terminal domain superfamily | STAT transcription factor, protein interaction | Transcription factor STAT |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M3B5U5 | InterPro | 708 | |||||||||||
UniProtKB:A0A8M9QF99 | InterPro | 634 | |||||||||||
UniProtKB:A0A8M9PRY3 | InterPro | 609 | |||||||||||
UniProtKB:A0A8M9Q4I2 | InterPro | 438 | |||||||||||
UniProtKB:A0A8M9QAL7 | InterPro | 683 | |||||||||||
UniProtKB:A0A8M9QJJ2 | InterPro | 640 | |||||||||||
UniProtKB:B0S789 | InterPro | 725 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA | ottdart00000001761 (1) | Havana | 682 nt | ||
mRNA | ottdart00000001848 (1) | Havana | 1,706 nt | ||
mRNA | ottdart00000056007 (1) | Havana | 1,527 nt | ||
mRNA |
stat1b-201
(1)
|
Ensembl | 4,113 nt | ||
mRNA |
stat1b-202
(1)
|
Ensembl | 535 nt | ||
mRNA |
stat1b-204
(1)
|
Ensembl | 3,189 nt | ||
ncRNA |
stat1b-003
(1)
|
Ensembl | 363 nt | ||
ncRNA |
stat1b-004
(1)
|
Ensembl | 812 nt |
Interactions and Pathways
No data available
Plasmids
No data available