ZFIN is now using GRCz12tu for Genomic Data
Gene

pomca

ID
ZDB-GENE-030513-2
Name
proopiomelanocortin a
Symbol
pomca Nomenclature History
Previous Names
  • pomc
  • ACTH
  • beta-endorphin
  • MSH
  • si:bz36d5.2
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Genome Assembly
GRCz12tu
Annotation Status
Current
Description
Enables neuropeptide hormone activity. Acts upstream of or within several processes, including melanosome localization; multicellular organismal response to stress; and regulation of hematopoietic stem cell differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including adenohypophyseal placode; adrenal medulla cell; bone tissue; endocrine system; and hypothalamus. Used to study hyperandrogenism. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; familial Mediterranean fever; nicotine dependence; obesity; and osteoarthritis. Orthologous to human POMC (proopiomelanocortin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
127 figures from 76 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
15 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pomca Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
early-onset obesity, adrenal insufficiency, and red hair Alliance Obesity, adrenal insufficiency, and red hair due to POMC deficiency 609734
obesity Alliance {Obesity, early-onset, susceptibility to} 601665
Associated With pomca Via Experimental Models
Human Disease Fish Conditions Citations
hyperandrogenism pomcaihb408/ihb408 standard conditions Shi et al., 2019
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013531 Pro-opiomelanocortin/corticotropin, ACTH, central region
Domain IPR013532 Opiodes neuropeptide
Domain IPR013593 Pro-opiomelanocortin N-terminal
Family IPR001941 Pro-opiomelanocortin
Family IPR050878 Pro-opiomelanocortin-derived peptides
Domain Details Per Protein
Protein Additional Resources Length Opiodes neuropeptide Pro-opiomelanocortin Pro-opiomelanocortin/corticotropin, ACTH, central region Pro-opiomelanocortin-derived peptides Pro-opiomelanocortin N-terminal
UniProtKB:Q7ZT18 InterPro 222
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA pomca-201 (1)
Ensembl
Ensembl 1,224 nt
ZFIN BLAST
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-aMSH polyclonal Rabbit
  • IHC
 Phoenix Pharmaceuticals, Inc.
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Genome Browsers
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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