Gene

dio1

ID
ZDB-GENE-030328-41
Name
iodothyronine deiodinase 1
Symbol
dio1 Nomenclature History
Previous Names
  • Deio1 (1)
  • cb685 (1)
  • zgc:92323
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have thyroxine 5'-deiodinase activity. Involved in regulation of neural retina development. Predicted to localize to integral component of membrane. Is expressed in several structures, including eye; female organism; heart; liver; and male organism. Orthologous to human DIO1 (iodothyronine deiodinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dio1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Thyroid hormone metabolism, abnormal, 2 619855
Associated With dio1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008261 Iodothyronine deiodinase, active site
Family IPR000643 Iodothyronine deiodinase
Homologous_superfamily IPR036249 Thioredoxin-like superfamily
Domain Details Per Protein
Protein Length Iodothyronine deiodinase Iodothyronine deiodinase, active site Thioredoxin-like superfamily
UniProtKB:A0A8M1P8S9 264
UniProtKB:A0A8M1N345 254
UniProtKB:A9JRP6 254
UniProtKB:Q802F6 241
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations