Gene
opn4.1
- ID
- ZDB-GENE-030314-2
- Name
- opsin 4.1
- Symbol
- opn4.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables photoreceptor activity. Acts upstream of or within phospholipase C-activating opsin-mediated signaling pathway and regulation of locomotor rhythm. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; heart; integument; testis; and visual system. Orthologous to human OPN4 (opsin 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zf3568 | Allele with one deletion | Exon 1 | Premature Stop | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-opn4.1 | N/A | Kokel et al., 2013 |
| TALEN1-opn4.1 | Dekens et al., 2022 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G-protein coupled receptor opsins | G protein-coupled receptor, rhodopsin-like | Opsin | Visual pigments (opsins) retinal binding site |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q1JPS6 | InterPro | 500 | |||||
| UniProtKB:G8Z410 | InterPro | 500 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
opn4.1-201
(1)
|
Ensembl | 3,192 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-154P10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:136728 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_178289 (1) | 3218 nt | ||
| Genomic | GenBank:BX323807 (2) | 194313 nt | ||
| Polypeptide | UniProtKB:G8Z410 (1) | 500 aa |
No data available
- Cao, M., Xu, T., Song, Y., Wei, S., Wang, H., Guo, X., Yin, D. (2024) Brominated Flame Retardant HBCD and Artificial Light at Night Synergically Caused Visual Disorder and Sleep Difficulty in Zebrafish Larvae. Environmental science & technology. 58(39):17247-17258
- Cao, M., Xu, T., Zhang, H., Wei, S., Wang, H., Song, Y., Guo, X., Chen, D., Yin, D. (2023) BDE-47 Causes Depression-like Effects in Zebrafish Larvae via a Non-Image-Forming Visual Mechanism. Environmental science & technology. 57(26):9592-9602
- Dekens, M.P.S., Fontinha, B.M., Gallach, M., Pflügler, S., Tessmar-Raible, K. (2022) Melanopsin elevates locomotor activity during the wake state of the diurnal zebrafish. EMBO reports. 23(5):e51528
- Liang, Q., Afriyie, G., Chen, Z., Xu, Z., Dong, Z., Wang, Z., Guo, Y. (2021) Analysis of Opsin Gene Family of Crimson Snapper (Lutjanus erythropterus). Gene. 807:145960
- Pende, M., Vadiwala, K., Schmidbaur, H., Stockinger, A.W., Murawala, P., Saghafi, S., Dekens, M.P.S., Becker, K., Revilla-I-Domingo, R., Papadopoulos, S.C., Zurl, M., Pasierbek, P., Simakov, O., Tanaka, E.M., Raible, F., Dodt, H.U. (2020) A versatile depigmentation, clearing, and labeling method for exploring nervous system diversity. Science advances. 6:eaba0365
- Qian, L., Qi, S., Wang, Z., Magnuson, J.T., Volz, D.C., Schlenk, D., Jiang, J., Wang, C. (2020) Environmentally relevant concentrations of boscalid exposure affects the neurobehavioral response of zebrafish by disrupting visual and nervous systems. Journal of hazardous materials. 404:124083
- Safarian, N., Whyte-Fagundes, P., Zoidl, C., Grigull, J., Zoidl, G. (2020) Visuomotor deficiency in panx1a knockout zebrafish is linked to dopaminergic signaling. Scientific Reports. 10:9538
- Steindal, I.A.F., Whitmore, D. (2020) Zebrafish Circadian Clock Entrainment and the Importance of Broad Spectral Light Sensitivity. Frontiers in Physiology. 11:1002
- Sousa, J.C., Magalhães-Marques, K.K., da Silveira Cruz-Machado, S., Moraes, M.N., Castrucci, A.M.L. (2017) Dexamethasone Modulates Nonvisual Opsins, Glucocorticoid Receptor, and Clock Genes in Danio rerio ZEM-2S Cells.. BioMed Research International. 2017:8459385
- Davies, W.I., Tamai, T.K., Zheng, L., Fu, J.K., Rihel, J., Foster, R.G., Whitmore, D., Hankins, M.W. (2015) An extended family of novel vertebrate photopigments is widely expressed and displays a diversity of function. Genome research. 25(11):1666-79
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