Gene
lmo7a
- ID
- ZDB-GENE-030219-74
- Name
- LIM domain 7a
- Symbol
- lmo7a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable cysteine-type deubiquitinase activity and metal ion binding activity. Predicted to be involved in positive regulation of macromolecule metabolic process and regulation of primary metabolic process. Predicted to act upstream of or within regulation of cell adhesion and regulation of signaling. Is expressed in several structures, including brain; digestive system; eye; immature eye; and pericardial region. Orthologous to human LMO7 (LIM domain 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa13371 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa17775 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa21468 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa25424 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa27385 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa34620 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa38736 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa45354 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
sa45355 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Calponin homology domain | CH domain superfamily | Domain of unknown function DUF4757 | LIM domain only protein 7 | PDZ domain | PDZ domain 6 | PDZ superfamily | Smooth muscle protein/calponin | Zinc finger, LIM-type |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M9QJM0 | InterPro | 1398 | |||||||||
UniProtKB:A0A8M9PS20 | InterPro | 1661 | |||||||||
UniProtKB:A0A8M9Q4J8 | InterPro | 1868 | |||||||||
UniProtKB:A0A8M9PS15 | InterPro | 1874 | |||||||||
UniProtKB:A0A8M9Q4K1 | InterPro | 1648 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-57A22 | ZFIN Curated Data | |
Encodes | EST | fc03h03 | ||
Encodes | EST | ibd5155 |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001128231 (1) | 6323 nt | ||
Genomic | GenBank:CR536604 (1) | 217381 nt | ||
Polypeptide | UniProtKB:A0AB32U1B3 (1) | 1905 aa |
- Li, Y.F., Cheng, T., Zhang, Y.J., Fu, X.X., Mo, J., Zhao, G.Q., Xue, M.G., Zhuo, D.H., Xing, Y.Y., Huang, Y., Sun, X.Z., Wang, D., Liu, X., Dong, Y., Zhu, X.S., He, F., Ma, J., Chen, D., Jin, X., Xu, P.F. (2022) Mycn regulates intestinal development through ribosomal biogenesis in a zebrafish model of Feingold syndrome 1. PLoS Biology. 20:e3001856
- Gomes, G., do Amaral, M.J., Bagri, K.M., Vasconcellos, L.M., Almeida, M.D.S., Alvares, L.E., Mermelstein, C. (2021) New Findings on LMO7 Transcripts, Proteins and Regulatory Regions in Human and Vertebrate Model Organisms and the Intracellular Distribution in Skeletal Muscle Cells. International Journal of Molecular Sciences. 22(23):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Takeuchi, M., Yamaguchi, S., Sakakibara, M., Hayashi, T., Matsuda, K., Hara, Y., Tanegashima, C., Shimizu, T., Kuraku, S., Hibi, M. (2017) Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. The Journal of comparative neurology. 525(7):1558-1585
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ott, E.B., van den Akker, N.M., Sakalis, P.A., Gittenberger-de Groot, A.C., Te Velthuis, A.J., and Bagowski, C.P. (2008) The lim domain only protein 7 is important in zebrafish heart development. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(12):3940-3952
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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