ZFIN is now using GRCz12tu for Genomic Data
Gene
mcm4
- ID
- ZDB-GENE-030131-9544
- Name
- minichromosome maintenance complex component 4
- Symbol
- mcm4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables chromatin binding activity. Acts upstream of or within response to yeast. Predicted to be located in chromosome. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in digestive system; nervous system; otic vesicle; pectoral fin; and proliferative region. Human ortholog(s) of this gene implicated in immunodeficiency 54. Orthologous to human MCM4 (minichromosome maintenance complex component 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1025 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 54 | Alliance | Immunodeficiency 54 | 609981 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018525 | Mini-chromosome maintenance, conserved site |
| Domain | IPR001208 | MCM domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR027925 | MCM, N-terminal domain |
| Domain | IPR033762 | MCM OB domain |
| Domain | IPR041562 | MCM, AAA-lid domain |
| Family | IPR008047 | Mini-chromosome maintenance complex protein 4 |
| Family | IPR031327 | Mini-chromosome maintenance protein |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Additional Resources | Length | AAA+ ATPase domain | MCM, AAA-lid domain | MCM domain | MCM, N-terminal domain | MCM OB domain | Mini-chromosome maintenance complex protein 4 | Mini-chromosome maintenance, conserved site | Mini-chromosome maintenance protein | Nucleic acid-binding, OB-fold | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6NZV2 | InterPro | 845 |
- Genome Browsers
- No data available
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-mcm4 | polyclonal | Rabbit |
|
Bethyl Laboratories, Inc.
|
2 |
Plasmids
No data available
- Genome Browsers