Gene

gars1

ID
ZDB-GENE-030131-9174
Name
glycyl-tRNA synthetase 1
Symbol
gars1 Nomenclature History
Previous Names
  • gars
  • mrn (1)
  • metronome (1)
  • si:dkey-276i5.1 (1)
  • wu:fb02f03 (1)
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to have glycine-tRNA ligase activity. Involved in translation. Predicted to localize to mitochondrion. Used to study Charcot-Marie-Tooth disease type 2. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2D and distal hereditary motor neuronopathy type 5A. Is expressed in several structures, including anterior neural keel; blood island; central nervous system; heart; and segmental plate. Orthologous to human GARS1 (glycyl-tRNA synthetase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gars1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Charcot-Marie-Tooth disease type 2D Alliance Charcot-Marie-Tooth disease, type 2D 601472
distal hereditary motor neuronopathy type 5A Alliance Neuronopathy, distal hereditary motor, type VA 600794
Spinal muscular atrophy, infantile, James type 619042
Associated With gars1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000738 WHEP-TRS domain
Domain IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
Domain IPR004154 Anticodon-binding
Domain IPR006195 Aminoacyl-tRNA synthetase, class II
Domain IPR033731 Glycyl-tRNA synthetase-like core domain
Family IPR002315 Glycyl-tRNA synthetase
Family IPR027031 Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2
Homologous_superfamily IPR009068 S15/NS1, RNA-binding
Homologous_superfamily IPR036621 Anticodon-binding domain superfamily
Homologous_superfamily IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class II Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) Anticodon-binding Anticodon-binding domain superfamily Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) Glycyl-tRNA synthetase Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2 Glycyl-tRNA synthetase-like core domain S15/NS1, RNA-binding WHEP-TRS domain
UniProtKB:F1QUV7 690
UniProtKB:Q4V9I4 764
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-gars polyclonal IgG Rabbit
  • WB
Abcam plc
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations