Gene

chek2

ID
ZDB-GENE-030131-8942
Name
checkpoint kinase 2
Symbol
chek2 Nomenclature History
Previous Names
  • chk2 (1)
  • fa66f08
  • wu:fa66f08
  • zgc:55865
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Involved in cellular response to DNA damage stimulus. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); colorectal cancer; osteosarcoma; and prostate cancer. Is expressed in eye; head; optic tectum; and proliferative region. Orthologous to human CHEK2 (checkpoint kinase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With chek2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Li-Fraumeni syndrome 2 Alliance Tumor predisposition syndrome 4, breast/prostate/colorectal 609265
osteosarcoma Alliance Osteosarcoma, somatic 259500
prostate cancer Alliance Prostate cancer, somatic 176807
Associated With chek2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Domain IPR000253 Forkhead-associated (FHA) domain
Domain IPR000719 Protein kinase domain
Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Forkhead-associated (FHA) domain Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site SMAD/FHA domain superfamily
UniProtKB:A0A8M2BC68 504
UniProtKB:Q803E2 503
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-chek2 polyclonal Rabbit
  • WB
Cell Signaling Technology, Inc.
2
Ab1-chek2 polyclonal Rabbit
  • WB
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations