Gene
scg2a
- ID
- ZDB-GENE-030131-8214
- Name
- secretogranin II a
- Symbol
- scg2a Nomenclature History
- Previous Names
-
- fj60f08
- sgIIa (1)
- wu:fj60f08
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to be located in extracellular region and secretory granule. Is expressed in brain; female organism; gut; and male organism. Orthologous to human SCG2 (secretogranin II).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
-
- GEO (1) Expression Atlas (1) Single Cell Expression Atlas (1) Daniocell (1)
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Tao et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Chromogranin A/B/C | Secretogranin-2 |
|---|---|---|---|---|
| UniProtKB:C0HM54 | InterPro | 539 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance
- Fleming, T., Tachizawa, M., Nishiike, Y., Koiwa, A., Homan, Y., Okubo, K. (2023) Estrogen-dependent expression and function of secretogranin 2a in female-specific peptidergic neurons. PNAS nexus. 2:pgad413pgad413
- Prendergast, A.E., Jim, K.K., Marnas, H., Desban, L., Quan, F.B., Djenoune, L., Laghi, V., Hocquemiller, A., Lunsford, E.T., Roussel, J., Keiser, L., Lejeune, F.X., Dhanasekar, M., Bardet, P.L., Levraud, J.P., van de Beek, D., Vandenbroucke-Grauls, C.M.J.E., Wyart, C. (2023) CSF-contacting neurons respond to Streptococcus pneumoniae and promote host survival during central nervous system infection. Current biology : CB. 33(5):940-956.e10
- Shaw, K., Lu, C., Liu, X., Trudeau, V.L. (2023) Arginine vasopressin injection rescues delayed oviposition in cyp19a1b-/- mutant female zebrafish. Frontiers in endocrinology. 14:13086751308675
- Ahi, E.P., Brunel, M., Tsakoumis, E., Chen, J., Schmitz, M. (2022) Appetite regulating genes in zebrafish gut; a gene expression study. PLoS One. 17:e0255201
- Mitchell, K., Mikwar, M., Da Fonte, D., Lu, C., Tao, B., Peng, D., Udeesha Erandani, W.K.C., Hu, W., Trudeau, V.L. (2020) Secretoneurin is a secretogranin-2 derived hormonal peptide in vertebrate neuroendocrine systems. General and comparative endocrinology. 299:113588
- Mitchell, K., Zhang, W.S., Lu, C., Tao, B., Chen, L., Hu, W., Trudeau, V.L. (2020) Targeted mutation of secretogranin-2 disrupts sexual behavior and reproduction in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 117(23):12772-12783
- Ahi, E.P., Brunel, M., Tsakoumis, E., Schmitz, M. (2019) Transcriptional study of appetite regulating genes in the brain of zebrafish (Danio rerio) with impaired leptin signalling. Scientific Reports. 9:20166
- Marvel, M.M., Spicer, O.S., Wong, T.T., Zmora, N., Zohar, Y. (2019) Knockout of Gnrh2 in zebrafish (Danio rerio) reveals its roles in regulating feeding behavior and oocyte quality. General and comparative endocrinology. 280:15-23
- Marvel, M., Spicer, O.S., Wong, T.T., Zmora, N., Zohar, Y. (2018) Knockout of the Gnrh genes in zebrafish: effects on reproduction and potential compensation by reproductive and feeding-related neuropeptides. Biology of reproduction. 99(3):565-577
- Tao, B., Hu, H., Mitchell, K., Chen, J., Jia, H., Zhu, Z., Trudeau, V.L., Hu, W. (2018) Secretogranin-II plays a critical role in zebrafish neurovascular modeling. Journal of molecular cell biology. 10(5):388-401
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