Gene
arf6a
- ID
- ZDB-GENE-030131-8007
- Name
- ADP-ribosylation factor 6a
- Symbol
- arf6a Nomenclature History
- Previous Names
-
- arf6
- wu:fj46d09
- zgc:77665
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable G protein activity and GTP binding activity. Acts upstream of or within intrahepatic bile duct development; regulation of apoptotic process; and spinal cord development. Predicted to be located in Flemming body; cleavage furrow; and filopodium membrane. Is expressed in intestinal bulb; liver; and pancreas. Orthologous to human ARF6 (ARF GTPase 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:77665 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ningappa et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-arf6a,arf6b | N/A | (4) |
| MO2-arf6a | N/A | Ningappa et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005225 | Small GTP-binding domain |
| Family | IPR006689 | Small GTPase superfamily, ARF/SAR type |
| Family | IPR024156 | Small GTPase superfamily, ARF type |
| Family | IPR041838 | ADP-ribosylation factor 6 |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ADP-ribosylation factor 6 | P-loop containing nucleoside triphosphate hydrolase | Small GTPase superfamily, ARF/SAR type | Small GTPase superfamily, ARF type | Small GTP-binding domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6P2U5 | InterPro | 175 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | ZFOS-2171E4 | ZFIN Curated Data | |
| Encodes | EST | fj46d09 | ||
| Encodes | cDNA | MGC:77665 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_199993 (1) | 1485 nt | ||
| Genomic | GenBank:CU693483 (1) | 27359 nt | ||
| Polypeptide | UniProtKB:Q6P2U5 (1) | 175 aa |
- Watson, S., LaVigne, C.A., Xu, L., Surdez, D., Cyrta, J., Calderon, D., Cannon, M.V., Kent, M.R., Silvius, K.M., Kucinski, J.P., Harrison, E.N., Murchison, W., Rakheja, D., Tirode, F., Delattre, O., Amatruda, J.F., Kendall, G.C. (2023) VGLL2-NCOA2 leverages developmental programs for pediatric sarcomagenesis. Cell Reports. 42:112013112013
- Seo, Y., Mo, S., Kim, S., Kim, H., Park, H.C. (2022) Tamalin Function Is Required for the Survival of Neurons and Oligodendrocytes in the CNS. International Journal of Molecular Sciences. 23(21):
- So, J., Ningappa, M., Glessner, J., Min, J., Ashokkumar, C., Ranganathan, S., Higgs, B.W., Li, D., Sun, Q., Schmitt, L., Biery, A.C., Dobrowolski, S., Trautz, C., Fuhrman, L., Schwartz, M.C., Klena, N.T., Fusco, J., Prasadan, K., Adenuga, M., Mohamed, N., Yan, Q., Chen, W., Horne, W., Dhawan, A., Sharif, K., Kelly, D., Squires, R.H., Gittes, G.K., Hakonarson, H., Morell, V., Lo, C., Subramaniam, S., Shin, D., Sindhi, R. (2020) Biliary-Atresia-Associated Mannosidase-1-Alpha-2 Gene Regulates Biliary and Ciliary Morphogenesis and Laterality. Frontiers in Physiology. 11:538701
- Fernandez, J.P., Moreno-Mateos, M.A., Gohr, A., Miao, L., Chan, S.H., Irimia, M., Giraldez, A.J. (2018) RES complex is associated with intron definition and required for zebrafish early embryogenesis. PLoS Genetics. 14:e1007473
- George, A.A., Hayden, S., Stanton, G.R., Brockerhoff, S.E. (2016) Arf6 and the 5'phosphatase of synaptojanin 1 regulate autophagy in cone photoreceptors. BioEssays : news and reviews in molecular, cellular and developmental biology. 38 Suppl 1:S119-35
- Smith, L.C., Clark, J.C., Bisesi, J.H., Ferguson, P.L., Sabo-Attwood, T. (2016) Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens. Comparative biochemistry and physiology. Part D, Genomics & proteomics. 19:159-73
- Ningappa, M., So, J., Glessner, J., Ashokkumar, C., Ranganathan, S., Min, J., Higgs, B.W., Sun, Q., Haberman, K., Schmitt, L., Vilarinho, S., Mistry, P.K., Vockley, G., Dhawan, A., Gittes, G.K., Hakonarson, H., Jaffe, R., Subramaniam, S., Shin, D., Sindhi, R. (2015) The Role of ARF6 in Biliary Atresia. PLoS One. 10:e0138381
- Lambaerts, K., Van Dyck, S., Mortier, E., Ivarssonm, Y., Degeest, G., Luyten, A., Vermeiren, E., Peers, B., David, G., and Zimmermann, P. (2012) Syntenin, a syndecan adaptor and an Arf6 phosphatidylinositol 4,5-bisphosphate effector, is essential for epiboly and gastrulation cell movements in zebrafish. Journal of Cell Science. 125(5):1129-1140
- Abramsson, A., Westman-Brinkmalm, A., Pannee, J., Gustavsson, M., von Otter, M., Blennow, K., Brinkmalm, G., Kettunen, P., and Zetterberg, H. (2010) Proteomics Profiling of Single Organs from Individual Adult Zebrafish. Zebrafish. 7(2):161-168
- Liu, H.Y., Lee, N., Tsai, T.Y., and Ho, S.Y. (2010) Zebrafish fat-free, a novel Arf effector, regulates phospholipase D to mediate lipid and glucose metabolism. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1801(12):1330-1340
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