Gene

lrpap1

ID

ZDB-GENE-030131-5871

Name

low density lipoprotein receptor-related protein associated protein 1

Symbol

lrpap1 Nomenclature History

Previous Names

wu:fi20f07
wu:fi22c06

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have heparin binding activity; low-density lipoprotein particle receptor binding activity; and receptor antagonist activity. Predicted to localize to endoplasmic reticulum. Human ortholog(s) of this gene implicated in Alzheimer's disease; dementia; myocardial infarction; and myopia. Is expressed in neural tube; otic placode; and pronephric duct. Orthologous to human LRPAP1 (LDL receptor related protein associated protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:56655 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lrpap1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
myopia	Alliance	Myopia 23, autosomal recessive	615431

Associated With lrpap1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR009066	Alpha-2-macroglobulin receptor-associated protein, domain 1
Domain	IPR010483	Alpha-2-macroglobulin RAP, C-terminal
Domain	IPR037999	Alpha-2-macroglobulin RAP, domain 3
Domain	IPR038001	Alpha-2-macroglobulin RAP, domain 2
Family	IPR038003	Alpha-2-macroglobulin receptor-associated protein
Homologous_superfamily	IPR036744	RAP domain superfamily