ZFIN is now using GRCz12tu for Genomic Data
Gene
tpte
- ID
- ZDB-GENE-030131-5503
- Name
- transmembrane phosphatase with tensin homology
- Symbol
- tpte Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables monoatomic ion channel activity and phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity. Acts upstream of or within phosphatidylinositol dephosphorylation and regulation of endocytosis. Predicted to be located in cell projection and membrane. Predicted to be active in cytosol. Is expressed in blood vessel; gill; pleuroperitoneal region; and ventral mesoderm. Orthologous to several human genes including TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6902478 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Ratanayotha et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR016130 | Protein-tyrosine phosphatase, active site |
| Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
| Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR014020 | Tensin phosphatase, C2 domain |
| Domain | IPR029023 | Tensin-type phosphatase domain |
| Domain | IPR045102 | TPTE, protein tyrosine phosphatase-like catalytic domain |
| Family | IPR051281 | Dual-specificity lipid and protein phosphatase |
| Homologous_superfamily | IPR027359 | Voltage-dependent channel domain superfamily |
| Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | C2 domain superfamily | Dual-specificity lipid and protein phosphatase | Ion transport domain | Protein-tyrosine phosphatase, active site | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Tensin phosphatase, C2 domain | Tensin-type phosphatase domain | TPTE, protein tyrosine phosphatase-like catalytic domain | Tyrosine-specific protein phosphatases domain | Voltage-dependent channel domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q4V9E4 | InterPro | 511 | |||||||||||
| UniProtKB:F1QG29 | InterPro PDB | 511 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-tpte | monoclonal | IgG2a | Mouse |
|
UC Davis/NIH NeuroMab Facility
|
2 |
Plasmids
- Genome Browsers