Gene

etfa

ID

ZDB-GENE-030131-4449

Name

electron transfer flavoprotein subunit alpha

Symbol

etfa Nomenclature History

Previous Names

cb1020 (1)
dark xavier (1)
wu:fd06h11 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable electron transfer activity and flavin adenine dinucleotide binding activity. Acts upstream of or within animal organ morphogenesis; mitochondrion organization; and regulation of fatty acid beta-oxidation. Predicted to be located in mitochondrial matrix. Predicted to be part of electron transfer flavoprotein complex. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; cardiovascular system; digestive system; musculature system; and nervous system. Used to study multiple acyl-CoA dehydrogenase deficiency. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFA (electron transfer flavoprotein subunit alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb1020 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 15 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With etfa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
multiple acyl-CoA dehydrogenase deficiency	Alliance	Glutaric acidemia IIA	231680

Associated With etfa Via Experimental Models

Human Disease	Fish	Conditions	Citations
multiple acyl-CoA dehydrogenase deficiency	etfa^vu463/vu463	standard conditions	Kim et al., 2013

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018206	Electron transfer flavoprotein subunit alpha, conserved site
Domain	IPR014730	Electron transfer flavoprotein, alpha/beta-subunit, N-terminal
Domain	IPR014731	Electron transfer flavoprotein, alpha subunit, C-terminal
Domain	IPR033947	Electron transfer flavoprotein, alpha subunit, N-terminal
Family	IPR001308	Electron transfer flavoprotein alpha subunit/FixB
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily	IPR029035	DHS-like NAD/FAD-binding domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	DHS-like NAD/FAD-binding domain superfamily	Electron transfer flavoprotein, alpha/beta-subunit, N-terminal	Electron transfer flavoprotein, alpha subunit, C-terminal	Electron transfer flavoprotein alpha subunit/FixB	Electron transfer flavoprotein, alpha subunit, N-terminal	Electron transfer flavoprotein subunit alpha, conserved site	Rossmann-like alpha/beta/alpha sandwich fold
UniProtKB:Q7ZUS9	InterPro	333

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	etfa-201 (1) Ensembl	Ensembl		1,607 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-etfa	polyclonal	etfa	IgG	Rabbit	IHC	GeneTex	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations