Gene

tardbpb

ID
ZDB-GENE-030131-3777
Name
TAR DNA binding protein b
Symbol
tardbpb Nomenclature History
Previous Names
  • tardbp
  • wu:fb77f02 (1)
  • wu:fc52g10 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Is predicted to enable RNA binding activity. Involved in regulation of gene expression. Acts upstream of or within several processes, including axon extension; neuromuscular junction development; and skeletal muscle tissue development. Predicted to be located in nucleus. Is expressed in several structures, including brain; eye; gill; heart; and liver. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Orthologous to human TARDBP (TAR DNA binding protein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tardbpb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
amyotrophic lateral sclerosis type 10 Alliance Amyotrophic lateral sclerosis 10, with or without FTD 612069
amyotrophic lateral sclerosis type 10 Alliance Frontotemporal lobar degeneration, TARDBP-related 612069
Associated With tardbpb Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000504 RNA recognition motif domain
Domain IPR041105 TAR DNA-binding protein 43, N-terminal
Homologous_superfamily IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
Homologous_superfamily IPR035979 RNA-binding domain superfamily
Domain Details Per Protein
Protein Length Nucleotide-binding alpha-beta plait domain superfamily RNA-binding domain superfamily RNA recognition motif domain TAR DNA-binding protein 43, N-terminal
UniProtKB:A0A2R8Q8T5 415
UniProtKB:Q802C7 412
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-tardbp polyclonal Rabbit
  • IHC
  • WB
Proteintech
4
Ab5-tardbp monoclonal IgG2a Rat
  • WB
2
Ab3-tardbp polyclonal Rabbit
Novus Biologicals, LLC
2
Ab6-tardbp polyclonal Rabbit
Sigma-Aldrich
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations