Gene

ptena

ID
ZDB-GENE-030131-3776
Name
phosphatase and tensin homolog A
Symbol
ptena Nomenclature History
Previous Names
  • wu:fc52g04
  • zgc:73086
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Exhibits lipid phosphatase activity. Involved in several processes, including lifelong otolith mineralization; phosphatidylinositol dephosphorylation; and regulation of protein kinase B signaling. Predicted to localize to PML body and cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome; PTEN hamartoma tumor syndrome; breast cancer (multiple); macrocephaly-autism syndrome; and nervous system cancer (multiple). Is expressed in several structures, including nervous system; otic vesicle; pectoral fin; presumptive neural retina; and ventral wall of dorsal aorta. Orthologous to human PTEN (phosphatase and tensin homolog).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ptena Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bannayan-Riley-Ruvalcaba syndrome Alliance Cowden syndrome 1 158350
Bannayan-Riley-Ruvalcaba syndrome Alliance Lhermitte-Duclos disease 158350
macrocephaly-autism syndrome Alliance Macrocephaly/autism syndrome 605309
prostate cancer Alliance Prostate cancer, somatic 176807
{Glioma susceptibility 2} 613028
{Meningioma} 607174
Associated With ptena Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR016130 Protein-tyrosine phosphatase, active site
Domain IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
Domain IPR000387 Tyrosine-specific protein phosphatases domain
Domain IPR003595 Protein-tyrosine phosphatase, catalytic
Domain IPR014020 Tensin phosphatase, C2 domain
Domain IPR029023 Tensin-type phosphatase domain
Domain IPR045101 PTEN, phosphatase domain
Family IPR017361 Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
Homologous_superfamily IPR029021 Protein-tyrosine phosphatase-like
Homologous_superfamily IPR035892 C2 domain superfamily
Domain Details Per Protein
Protein Length Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN C2 domain superfamily Protein-tyrosine phosphatase, active site Protein-tyrosine phosphatase, catalytic Protein-tyrosine phosphatase-like PTEN, phosphatase domain Tensin phosphatase, C2 domain Tensin-type phosphatase domain Tyrosine-specific protein phosphatase, PTPase domain Tyrosine-specific protein phosphatases domain
UniProtKB:Q6TGR7 431
UniProtKB:F6NM25 452
UniProtKB:Q6TGR6 454
UniProtKB:E7FC59 467
UniProtKB:A0A2R8PY11 358
UniProtKB:A0A2R8Q8H3 421
UniProtKB:A0A2R8RK27 398
UniProtKB:F1Q5Y5 444
UniProtKB:Q6PC66 452
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ptena monoclonal IgG Rabbit
  • IHC
  • WB
Cell Signaling Technology, Inc.
7
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations