Gene

plod1a

ID

ZDB-GENE-030131-3165

Name

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1a

Symbol

plod1a Nomenclature History

Previous Names

lh1 (1)
plod1
plod (1)
fc95g08
fi18a05
ik:tdsubs_rzpd609-29b19
wu:fc29c10
wu:fc95g08 (1)
wu:fi18a05
zgc:152876

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have procollagen-lysine 5-dioxygenase activity. Involved in fin morphogenesis. Predicted to localize to endoplasmic reticulum. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome. Is expressed in several structures, including cranium; notochord; otic vesicle; pectoral fin; and shield. Orthologous to human PLOD1 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Durán et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With plod1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Ehlers-Danlos syndrome kyphoscoliotic type 1	Alliance	Ehlers-Danlos syndrome, kyphoscoliotic type, 1	225400

Associated With plod1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001006	Procollagen-lysine 5-dioxygenase, conserved site
Domain	IPR005123	Oxoglutarate/iron-dependent dioxygenase
Domain	IPR006620	Prolyl 4-hydroxylase, alpha subunit
Domain	IPR044861	Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain
Homologous_superfamily	IPR029044	Nucleotide-diphospho-sugar transferases

Domain Details Per Protein

Protein	Length	Isopenicillin N synthase-like, Fe(2+) 2OG dioxygenase domain	Nucleotide-diphospho-sugar transferases	Oxoglutarate/iron-dependent dioxygenase	Procollagen-lysine 5-dioxygenase, conserved site	Prolyl 4-hydroxylase, alpha subunit
UniProtKB:A8WIN7 InterPro	730

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	plod1a-203 (1) Ensembl	Havana	664 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	plod1a-201 (1) Ensembl	Havana	2767 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	plod1a-003 (1) Ensembl	Havana	406 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations