Gene
podxl
- ID
- ZDB-GENE-030131-2805
- Name
- podocalyxin-like
- Symbol
- podxl Nomenclature History
- Previous Names
-
- fc18d02
- si:dkey-146n1.1
- wu:fc18d02
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Acts upstream of or within pronephric glomerulus morphogenesis. Predicted to be located in several cellular components, including lamellipodium; microvillus; and ruffle. Predicted to be active in apical plasma membrane and microvillus membrane. Is expressed in cardiovascular system; hindbrain neural keel; pronephros; and yolk syncytial layer. Orthologous to human PODXL (podocalyxin like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1088 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Ichimura et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-podxl | N/A | Ichimura et al., 2013 |
| MO2-podxl | N/A | Ichimura et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CD34/Podocalyxin | Podocalyxin |
|---|---|---|---|---|
| UniProtKB:Q5RHU2 | InterPro | 445 | ||
| UniProtKB:A0AB32TK41 | InterPro | 392 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-0.2myl7:tdTomato-podxl) |
|
| 1 | Rasouli et al., 2018 | |
| Tg(4xnrUAS:EGFP-podxl,myl7:EGFP) |
|
| 1 | Lee et al., 2021 | |
| Tg(fli1:EGFP-podxl) |
|
| 1 | (2) | |
| Tg(hsp70l:GFP-podxl) |
|
| 1 | (4) | |
| Tg(myl7:EGFP-podxl) |
|
| 1 | (7) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-146N1 | ZFIN Curated Data | |
| Encodes | EST | eu1088 | Thisse et al., 2005 | |
| Encodes | EST | fc18d02 | ||
| Encodes | cDNA | MGC:158122 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195019 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195035 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045016 (1) | 4227 nt | ||
| Genomic | GenBank:BX465862 (2) | 214562 nt | ||
| Polypeptide | UniProtKB:Q5RHU2 (1) | 445 aa |
- Yin, J., Schellinx, N., Maggi, L., Gundel, K., Wiesner, C., Kotini, M.P., Lee, M., Phng, L.K., Belting, H.G., Affolter, M. (2024) Initiation of lumen formation from junctions via differential actomyosin contractility regulated by dynamic recruitment of Rasip1. Nature communications. 15:97149714
- Chow, R.W., Fukui, H., Chan, W.X., Tan, K.S.J., Roth, S., Duchemin, A.L., Messaddeq, N., Nakajima, H., Liu, F., Faggianelli-Conrozier, N., Klymchenko, A.S., Choon Hwai, Y., Mochizuki, N., Vermot, J. (2022) Cardiac forces regulate zebrafish heart valve delamination by modulating Nfat signaling. PLoS Biology. 20:e3001505
- Das, R.N., Tevet, Y., Safriel, S., Han, Y., Moshe, N., Lambiase, G., Bassi, I., Nicenboim, J., Brückner, M., Hirsch, D., Eilam-Altstadter, R., Herzog, W., Avraham, R., Poss, K.D., Yaniv, K. (2022) Generation of specialized blood vessels via lymphatic transdifferentiation. Nature. 606(7914):570-575
- Xia, Y., Duca, S., Perder, B., Dündar, F., Zumbo, P., Qiu, M., Yao, J., Cao, Y., Harrison, M.R.M., Zangi, L., Betel, D., Cao, J. (2022) Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration. Nature communications. 13:77047704
- Abu Nahia, K., Migdał, M., Quinn, T.A., Poon, K.L., Łapiński, M., Sulej, A., Liu, J., Mondal, S.S., Pawlak, M., Bugajski, Ł., Piwocka, K., Brand, T., Kohl, P., Korzh, V., Winata, C. (2021) Genomic and physiological analyses of the zebrafish atrioventricular canal reveal molecular building blocks of the secondary pacemaker region. Cellular and molecular life sciences : CMLS. 78(19-20):6669-6687
- Brown, C., Mullins, L.J., Wesencraft, K., McConnell, G., Beltran, M., Henderson, N.C., Conway, B., Hoffmann, S., Rider, S., Mullins, J.J. (2021) scRNA Transcription Profile of Adult Zebrafish Podocytes Using a Novel Reporter Strain. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 55:35-47
- Gentile, A., Bensimon-Brito, A., Priya, R., Maischein, H.M., Piesker, J., Guenther, S., Gunawan, F., Stainier, D.Y. (2021) The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression. eLIFE. 10:
- Lee, M., Betz, C., Yin, J., Paatero, I., Schellinx, N., Carte, A.N., Wilson, C.W., Ye, W., Affolter, M., Belting, H.G. (2021) Control of dynamic cell behaviors during angiogenesis and anastomosis by Rasip1. Development (Cambridge, England). 148(15):
- Sarvari, P., Rasouli, S.J., Allanki, S., Stone, O.A., Sokol, A., Graumann, J., Stainier, D.Y.R. (2021) The E3 ubiquitin-protein ligase Rbx1 regulates cardiac wall morphogenesis in zebrafish. Developmental Biology. 480:1-12
- Priya, R., Allanki, S., Gentile, A., Mansingh, S., Uribe, V., Maischein, H.M., Stainier, D.Y.R. (2020) Tension heterogeneity directs form and fate to pattern the myocardial wall. Nature. 588(7836):130-134
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