Gene

top2a

ID
ZDB-GENE-030131-2453
Name
DNA topoisomerase II alpha
Symbol
top2a Nomenclature History
Previous Names
  • fc08c07
  • wu:fc08c07
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in animal organ regeneration and chromosome segregation. Predicted to localize to DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex and nucleus. Is expressed in digestive system; head; nervous system; neural tube; and pectoral fin. Orthologous to human TOP2A (DNA topoisomerase II alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With top2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
DNA topoisomerase II, resistance to inhibition of, by amsacrine
Associated With top2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018522 DNA topoisomerase, type IIA, conserved site
Domain IPR002205 DNA topoisomerase, type IIA, domain A
Domain IPR003594 Histidine kinase/HSP90-like ATPase
Domain IPR006171 TOPRIM domain
Domain IPR012542 DTHCT
Domain IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2
Domain IPR031660 C-terminal associated domain of TOPRIM
Domain IPR034157 DNA topoisomerase 2, TOPRIM domain
Family IPR001241 DNA topoisomerase, type IIA
Homologous_superfamily IPR013757 DNA topoisomerase, type IIA, alpha-helical domain superfamily
Homologous_superfamily IPR013758 DNA topoisomerase, type IIA, domain A, alpha-beta
Homologous_superfamily IPR013759 DNA topoisomerase, type IIA, subunit B, C-terminal
Homologous_superfamily IPR013760 DNA topoisomerase, type IIA-like domain superfamily
Homologous_superfamily IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
Homologous_superfamily IPR020568 Ribosomal protein S5 domain 2-type fold
Homologous_superfamily IPR036890 Histidine kinase/HSP90-like ATPase superfamily
Domain Details Per Protein
Protein Length C-terminal associated domain of TOPRIM DNA topoisomerase 2, TOPRIM domain DNA topoisomerase, type IIA DNA topoisomerase, type IIA, alpha-helical domain superfamily DNA topoisomerase, type IIA, conserved site DNA topoisomerase, type IIA, domain A DNA topoisomerase, type IIA, domain A, alpha-beta DNA topoisomerase, type IIA-like domain superfamily DNA topoisomerase, type IIA, subunit B, C-terminal DNA topoisomerase, type IIA, subunit B, domain 2 DTHCT Histidine kinase/HSP90-like ATPase Histidine kinase/HSP90-like ATPase superfamily Ribosomal protein S5 domain 2-type fold Ribosomal protein S5 domain 2-type fold, subgroup TOPRIM domain
UniProtKB:A8E7K3 810
UniProtKB:A0A0R4IUF0 1570
UniProtKB:Q6DRC7 1574
UniProtKB:A8KC57 349
UniProtKB:Q5PQY4 1570
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations