Gene
azin1b
- ID
- ZDB-GENE-030121-1
- Name
- antizyme inhibitor 1b
- Symbol
- azin1b Nomenclature History
- Previous Names
-
- azin1
- oazin (1)
- wu:fj32d12
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to enable ornithine decarboxylase activator activity and ornithine decarboxylase activity. Predicted to be involved in negative regulation of protein catabolic process; positive regulation of polyamine transmembrane transport; and putrescine biosynthetic process from arginine, via ornithine. Predicted to act upstream of or within polyamine biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and liver cirrhosis. Orthologous to human AZIN1 (antizyme inhibitor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7150958 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
sa29231 | Allele with one point mutation | Unknown | Splice Site | ENU |
1 - 1 of 1
Show
No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR022657 | Orn/DAP/Arg decarboxylase 2, conserved site |
Domain | IPR022643 | Orn/DAP/Arg decarboxylase 2, C-terminal |
Domain | IPR022644 | Orn/DAP/Arg decarboxylase 2, N-terminal |
Family | IPR000183 | Ornithine/DAP/Arg decarboxylase |
Family | IPR002433 | Ornithine decarboxylase |
1 - 5 of 8 Show all
Domain Details Per Protein
Protein | Additional Resources | Length | Alanine racemase/group IV decarboxylase, C-terminal | Antizyme inhibitor 1 | Orn/DAP/Arg decarboxylase 2, conserved site | Orn/DAP/Arg decarboxylase 2, C-terminal | Orn/DAP/Arg decarboxylase 2, N-terminal | Ornithine/DAP/Arg decarboxylase | Ornithine decarboxylase | PLP-binding barrel |
---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q801V3 | InterPro | 436 |
1 - 1 of 1
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
azin1b-201
(1)
|
Ensembl | 2,808 nt | ||
mRNA |
azin1b-202
(1)
|
Ensembl | 727 nt | ||
mRNA |
azin1b-203
(1)
|
Ensembl | 2,446 nt |
1 - 3 of 3
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-215I13 | ZFIN Curated Data | |
Encodes | EST | fj32d12 | ||
Encodes | EST | IMAGE:7150958 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:66049 | ZFIN Curated Data |
1 - 4 of 4
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001007159 (1) | 2811 nt | ||
Genomic | GenBank:AL807244 (2) | 201745 nt | ||
Polypeptide | UniProtKB:Q801V3 (1) | 436 aa |
- Haws, W., England, S., Grieb, G., Susana, G., Hernandez, S., Mirer, H., Lewis, K. (2023) Analyses of binding partners and functional domains for the developmentally essential protein Hmx3a/HMX3. Scientific Reports. 13:11511151
- Cambier, S., Røgeberg, M., Georgantzopoulou, A., Serchi, T., Karlsson, C., Verhaegen, S., Iversen, T.G., Guignard, C., Kruszewski, M., Hoffmann, L., Audinot, J.N., Ropstad, E., Gutleb, A.C. (2018) Fate and effects of silver nanoparticles on early life-stage development of zebrafish (Danio rerio) in comparison to silver nitrate. The Science of the total environment. 610-611:972-982
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Kassahn, K.S., Dang, V.T., Wilkins, S.J., Perkins, A.C., and Ragan, M.A. (2009) Evolution of gene function and regulatory control after whole-genome duplication: Comparative analyses in vertebrates. Genome research. 19(8):1404-1418
- Ng, Y.K., Wu, W., and Zhang, L. (2009) Positive correlation between gene coexpression and positional clustering in the zebrafish genome. BMC Genomics. 10:42
- Hoffmann, J.L., Thomason, R.G., Lee, D.M., Brill, J.L., Price, B.B., Carr, G.J., and Versteeg, D.J. (2008) Hepatic gene expression profiling using GeneChips in zebrafish exposed to 17alpha-methyldihydrotestosterone. Aquatic toxicology (Amsterdam, Netherlands). 87(2):69-80
- Zeng, J., Yan, J., Wang, T., Mosbrook-Davis, D., Dolan, K.T., Christensen, R., Stormo, G.D., Haussler, D., Lathrop, R.H., Brachmann, R.K., and Burgess, S.M. (2008) Genome wide screens in yeast to identify potential binding sites and target genes of DNA-binding proteins. Nucleic acids research. 36(1):e8
- Hascilowicz, T., Murai, N., Matsufuki, S., and Murakami, Y. (2002) Regulation of ornithine decarboxylase by antizymes and antizyme inhibitor in zebrafish (Danio rerio). BBA Gene Structure and Expression. 1578(1-3):21-28
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 9 of 9
Show