Gene

azin1b

ID
ZDB-GENE-030121-1
Name
antizyme inhibitor 1b
Symbol
azin1b Nomenclature History
Previous Names
  • azin1
  • oazin (1)
  • wu:fj32d12
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Predicted to enable ornithine decarboxylase activator activity and ornithine decarboxylase activity. Predicted to be involved in negative regulation of protein catabolic process; positive regulation of polyamine transmembrane transport; and putrescine biosynthetic process from arginine, via ornithine. Predicted to act upstream of or within polyamine biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and liver cirrhosis. Orthologous to human AZIN1 (antizyme inhibitor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa29231Allele with one point mutationUnknownSplice SiteENU
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Sequence Targeting Reagents
No data available
Human Disease
Associated With azin1b Human Ortholog
No data available
Associated With azin1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR022657 Orn/DAP/Arg decarboxylase 2, conserved site
Domain IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal
Domain IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal
Family IPR000183 Ornithine/DAP/Arg decarboxylase
Family IPR002433 Ornithine decarboxylase
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Domain Details Per Protein
Protein Additional Resources Length Alanine racemase/group IV decarboxylase, C-terminal Antizyme inhibitor 1 Orn/DAP/Arg decarboxylase 2, conserved site Orn/DAP/Arg decarboxylase 2, C-terminal Orn/DAP/Arg decarboxylase 2, N-terminal Ornithine/DAP/Arg decarboxylase Ornithine decarboxylase PLP-binding barrel
UniProtKB:Q801V3 InterPro 436
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 19
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA azin1b-201 (1) Ensembl 2,808 nt
mRNA azin1b-202 (1) Ensembl 727 nt
mRNA azin1b-203 (1) Ensembl 2,446 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-215I13ZFIN Curated Data
EncodesESTfj32d12
EncodesESTIMAGE:7150958Thisse et al., 2004
EncodescDNAMGC:66049ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanAZIN18
Conserved genome location (synteny) (1)
Amino acid sequence comparison (2)
MouseAzin115
Conserved genome location (synteny) (1)
Amino acid sequence comparison (1)
Citations
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