ZFIN is now using GRCz12tu for Genomic Data

Gene

ttn.2

ID

ZDB-GENE-030113-2

Name

titin, tandem duplicate 2

Symbol

ttn.2 Nomenclature History

Previous Names

TTN2 (1)
ttn
ttna
pickwick
pik
si:busm1-258d18.1
si:dz258d18.1
wu:fi04b11
wu:fi20g08

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Genome Assembly

GRCz11

Annotation Status

Unknown

Description

A structural constituent of muscle. Acts upstream of or within several processes, including heart contraction; myofibril assembly; and striated muscle tissue development. Is active in centriole; cytoplasm; and nucleus. Is expressed in several structures, including cardiovascular system; mesoderm; musculature system; somite; and testis. Used to study atrial fibrillation and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and myopathy (multiple). Orthologous to human TTN (titin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

61 figures from 27 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7148926 (11 images)
IMAGE:7159525 (15 images)
IMAGE:7157159 (18 images)
IMAGE:7153193 (16 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 41 figures from 15 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ttn.2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive limb-girdle muscular dystrophy type 2J	Alliance	Muscular dystrophy, limb-girdle, autosomal recessive 10	608807
congenital myopathy 5	Alliance	Congenital myopathy 5 with cardiomyopathy	611705
dilated cardiomyopathy 1G	Alliance	Cardiomyopathy, dilated, 1G	604145
hypertrophic cardiomyopathy 9	Alliance	Cardiomyopathy, familial hypertrophic, 9	613765
myofibrillar myopathy 9	Alliance	Myopathy, myofibrillar, 9, with early respiratory failure	603689
tibial muscular dystrophy	Alliance	Tibial muscular dystrophy, tardive	600334

Associated With ttn.2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
atrial fibrillation	ttn.2^sfc9/+	standard conditions	Ahlberg et al., 2018
atrial fibrillation	ttn.2^sfc9/sfc9	standard conditions	Ahlberg et al., 2018
dilated cardiomyopathy	ttn.2^vcc14/+	standard conditions	Huttner et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

No data available

Domain Details Per Protein

No data available

Transcripts

Genome Browsers

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ottdart00000002029 (1)	Havana	58,230 nt	Select Tool
mRNA	ttn.2-201 (1) Ensembl	Ensembl	23,044 nt	Select Tool ZFIN BLAST
mRNA	ttn.2-203 (1) Ensembl	Ensembl	67,298 nt	Select Tool ZFIN BLAST
mRNA	ttn.2-204 (1) Ensembl	Ensembl	1,201 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab2-ttn	monoclonal	ttn.2		Mouse	IHC		2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations