Gene
hspd1
- ID
- ZDB-GENE-021206-1
- Name
- heat shock 60 protein 1
- Symbol
- hspd1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have unfolded protein binding activity. Involved in fin regeneration; regulation of cell population proliferation; and regulation of neutrophil chemotaxis. Localizes to mitochondrial matrix. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autistic disorder; glucose intolerance; hereditary spastic paraplegia (multiple); and hypomyelinating leukodystrophy 4. Is expressed in several structures, including anterior neural keel; digestive system; mesoderm; musculature system; and nervous system. Orthologous to human HSPD1 (heat shock protein family D (Hsp60) member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 38 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb144 (20 images)
- cb863 (12 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary spastic paraplegia 13 | Alliance | Spastic paraplegia 13, autosomal dominant | 605280 |
| hypomyelinating leukodystrophy 4 | Alliance | Leukodystrophy, hypomyelinating, 4 | 612233 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018370 | Chaperonin Cpn60, conserved site |
| Family | IPR001844 | Chaperonin Cpn60/GroEL |
| Family | IPR002423 | Chaperonin Cpn60/GroEL/TCP-1 family |
| Homologous_superfamily | IPR027409 | GroEL-like apical domain superfamily |
| Homologous_superfamily | IPR027410 | TCP-1-like chaperonin intermediate domain superfamily |
| Homologous_superfamily | IPR027413 | GroEL-like equatorial domain superfamily |
Domain Details Per Protein
| Protein | Length | Chaperonin Cpn60, conserved site | Chaperonin Cpn60/GroEL | Chaperonin Cpn60/GroEL/TCP-1 family | GroEL-like apical domain superfamily | GroEL-like equatorial domain superfamily | TCP-1-like chaperonin intermediate domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q803B0
|
575 |
Interactions and Pathways
No data available
Plasmids
No data available