ZFIN is now using GRCz12tu for Genomic Data
Gene
dnah9
- ID
- ZDB-GENE-020925-1
- Name
- dynein, axonemal, heavy chain 9
- Symbol
- dnah9 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable several functions, including ATP binding activity; dynein intermediate chain binding activity; and dynein light intermediate chain binding activity. Acts upstream of or within determination of heart left/right asymmetry and epithelial cilium movement involved in determination of left/right asymmetry. Located in extracellular region. Is expressed in several structures, including mesoderm; nervous system; neural tube; pleuroperitoneal region; and tail bud. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 40. Orthologous to human DNAH9 (dynein axonemal heavy chain 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 34 figures from 19 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:63607 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Chen et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dnah9 | Wang et al., 2021 | |
| CRISPR2-dnah9 | Wang et al., 2021 | |
| CRISPR3-dnah9 | Wang et al., 2021 | |
| CRISPR4-dnah9 | Wang et al., 2021 | |
| MO1-dnah9 | N/A | (3) |
| MO2-dnah9 | N/A | Essner et al., 2005 |
| MO3-dnah9 | N/A | (2) |
| MO4-dnah9 | N/A | Chen et al., 2022 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary ciliary dyskinesia 40 | Alliance | Ciliary dyskinesia, primary, 40 | 618300 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dynein heavy chain | Dynein heavy chain 3, AAA+ lid domain | Dynein heavy chain, AAA1 domain, small subdomain | Dynein heavy chain, AAA 5 extension domain | Dynein heavy chain AAA lid domain | Dynein heavy chain AAA lid domain superfamily | Dynein heavy chain, AAA module D4 | Dynein heavy chain, ATP-binding dynein motor region | Dynein heavy chain, coiled coil stalk | Dynein heavy chain, C-terminal domain | Dynein heavy chain, C-terminal domain, barrel region | Dynein heavy chain, domain 2, N-terminal | Dynein heavy chain, hydrolytic ATP-binding dynein motor region | Dynein heavy chain, linker | Dynein heavy chain, linker, subdomain 3 | Dynein heavy chain region D6 P-loop domain | Dynein heavy chain, tail | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB13A7H0 | InterPro | 4464 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | Fosmid | CH1073-80J9 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:63607 |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001366550 (1) | 13514 nt | ||
| Genomic | GenBank:FO818699 (1) | 39158 nt | ||
| Polypeptide | UniProtKB:A0AB13A7H0 (1) | 4464 aa |
- Kurup, A.J., Bailet, F., Fürthauer, M. (2024) Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry. Nature communications. 15:65476547
- Rayamajhi, D., Ege, M., Ukhanov, K., Ringers, C., Zhang, Y., Jung, I., D'Gama, P.P., Li, S.S., Cosacak, M.I., Kizil, C., Park, H.C., Yaksi, E., Martens, J.R., Brody, S.L., Jurisch-Yaksi, N., Roy, S. (2024) The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation. PLoS Biology. 22:e3002468e3002468
- Yao, W., Wei, Z., Tian, X., Tan, J., Liu, J. (2024) Gdf11 regulates left-right asymmetry development through TGF-β signal. Cell Proliferation. :e13765e13765
- Chen, W., Zhang, Y., Shen, L., Zhu, J., Cai, K., Lu, Z., Zeng, W., Zhao, J., Zhou, X. (2022) Biallelic DNAH9 mutations are identified in Chinese patients with defective left-right patterning and cilia-related complex congenital heart disease. Human genetics. 141(8):1339-1353
- Wang, Y., Troutwine, B.R., Zhang, H., Gray, R.S. (2021) The axonemal dynein heavy chain 10 gene is essential for monocilia motility and spine alignment in zebrafish. Developmental Biology. 482:82-90
- Zhu, C., Guo, Z., Zhang, Y., Liu, M., Chen, B., Cao, K., Wu, Y., Yang, M., Yin, W., Zhao, H., Tai, H., Ou, Y., Yu, X., Liu, C., Li, S., Su, B., Feng, Y., Huang, S. (2019) Aplnra/b Sequentially Regulate Organ Left-Right Patterning via Distinct Mechanisms. International journal of biological sciences. 15:1225-1239
- Ferreira, R.R., Pakula, G., Klaeyle, L., Fukui, H., Vilfan, A., Supatto, W., Vermot, J. (2018) Chiral Cilia Orientation in the Left-Right Organizer. Cell Reports. 25:2008-2016.e4
- Warga, R.M., Kane, D.A. (2018) Probing Cadherin Interactions in Zebrafish with E- and N-Cadherin Missense Mutants. Genetics. 210(4):1391-1409
- Yamaguchi, H., Oda, T., Kikkawa, M., Takeda, H. (2018) Systematic studies of all PIH proteins in zebrafish reveal their distinct roles in axonemal dynein assembly. eLIFE. 7
- Tavares, B., Jacinto, R., Sampaio, P., Pestana, S., Pinto, A., Vaz, A., Roxo-Rosa, M., Gardner, R., Lopes, T., Schilling, B., Henry, I., Saúde, L., Lopes, S.S. (2017) Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Foxj1a in zebrafish left-right organizer.. eLIFE. 6
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