Gene

aurkb

ID
ZDB-GENE-020419-40
Name
aurora kinase B
Symbol
aurkb Nomenclature History
Previous Names
  • aurB (1)
  • cei
  • cellular island
  • CHUNP6896
  • fa09g06
  • fd02h12
  • stka
  • wu:fa09g06
  • wu:fd02h12
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have histone serine kinase activity. Involved in chromosome segregation; cytoskeleton-dependent cytokinesis; and microtubule cytoskeleton organization. Predicted to localize to condensed nuclear chromosome, centromeric region; microtubule cytoskeleton; and midbody. Human ortholog(s) of this gene implicated in spermatogenic failure 5. Is expressed in several structures, including blastomere; midbrain hindbrain boundary; nervous system; and proliferative region. Orthologous to human AURKB (aurora kinase B) and AURKC (aurora kinase C).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
12 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With aurkb Human Ortholog
No data available
Associated With aurkb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Family IPR028772 Aurora kinase B
Family IPR030616 Aurora kinase
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Aurora kinase Aurora kinase B Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:Q6NW76 320
UniProtKB:F1RDC1 320
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-aurkb polyclonal Rabbit
  • IHC
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations